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]]>2-Acetoxy-N,N,N-trimethylethanaminium
Classification
Acetylcholine is a cholinergic agonist. It is a choline ester.
Physiochemical Properties
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 146.21 g/mol |
2 | Physical appearance | Present in solid form. |
3 | Melting point | 148°C. |
4 | Solubility | 600gm/L in water |
5 | Presence of ring | Not present |
6 | Number of chiral centers | Not present |
Mechanism of Action
The mechanism of action of acetylcholine is as a cholinergic agonist.
Structure Activity Relationship
Method of synthesis
Trimethylamine and 2-chloroethyl acetate reacts together to give acetylcholine.
Therapeutic Uses
Acetylcholine is used for treatment of:
Side Effects
Side effects of acetylcholine are:
Ocular side effects:
Systemic side effects:
MCQs
Q.1 “2-Acetoxy-N,N,N-trimethylethanaminium” is the IUPAC nomenclature of which drug?
a) Acetylcholine
b) Cevimeline
c) Trospium chloride
d) Carvedilol
Q.2 Molecular weight of Acetylcholine is?
a) 146.21 gm/mol
b) 199.32 gm/mol
c) 428 gm/mol
d) 406.5 gm/mol
Q.3 Match the following with correct classifications of the drugs.
i. Cavedilol | A. Antispasmodic agent |
ii. Trospium chloride | B. Cholinergic agonist. Choline ester. |
iii. Acetylcholine | C. Mixed α/ß blocker |
iv. Metocurine | D. Nicotinic antagonist |
a) i-,B ii-,C iii-A, iv-D
b) i-D, ii-A, iii-C, iv-B
c) i-C, ii-A, iii-B, iv-D
d) i-B, ii-A, iii-C, iv-A
Q.4 Mechanism of action of Acetylcholine can be due to?
a) Antagonism of cholinergic receptors
b) Agonism of cholinergic receptors
c) Anticholinestrase inhibition
d) Anticholinestrase Stimulation
Q.5 Correct sequence for True and False for the given statements related with the SAR of drug acetylcholine.
When the nitrogen of the quaternary ammonium group is replaced with arsenic, phosphorous, sulfur or selenium, their activity Increases.
It is necessary for the atom present at the nitrogen position to have a Negative charge to have muscarinic activity.
When all three methyl groups are replaced by larger alkyl groups at the quaternary nitrogen, drug becomes inactive as agonist.
When all the methyl groups associated with the quaternary nitrogen atom are replaced by ethyl groups, the compound becomes cholinergic antagonist.
a) TTFF
b) FTFT
c) TFFT
d) FFTF
Q.6 Trimethylamine and 2-chloroethylacetate reacts together to give?
a) Cevimeline
b) Acetylcholine
c) Zolpidem
d) Trospium chloride
Q.7 The drug Acetylcholine is mainly used for?
a) Alzhiemer’s disease
b) Myasthenia gravis
c) Reversing action of muscle relaxants
d) All of the above
ANSWERS
1-a
2-a
3-c
4-b
5-a
6-b
7-d
REFERENCES
[1] Lemke TL, Williams DA, Foye WO. Principles of medicinal chemistry. Williams & Wilkins; 2017, 320.
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