The post AMOBARBITAL Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
]]>5-ethyl-5-(3-methylbutyl)-1,3-diazinane-2,4,6-trione.
Amobarbital is a barbiturate sedative-hypnotic.
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 226.27 g/mol |
2 | Physical appearance | White crystalline solid |
3 | Melting point | 157°C |
4 | Octanol/water partition coefficient | 2.07 |
5 | Solubility | 1 g dissolves in: 1300 mL of water |
6 | Presence of ring | Pyrimidine |
7 | Number of chiral centers | 1 |
i. Diethyl malonate reacts with sodium ethoxide followed by reaction with ethylbromide to give diethyl 2-ethylmalonate.
ii. The compound undergoes reaction with 1-bromo-3-methylbutane to produce diethyl 2-ethyl-2-isopentylmalonate.
iii. The above formed compound on condensation with urea yields amobarbital.
Amobarbital is used for:
Side effects of Amobarbital are:
MCQ
Q.1 What can be the correct IUPAC nomenclature of Amobarbital
a) 5-ethyl-5-(3-methylbutyl)-1,3-diazinane-2,4,6-trione
b) 3-ethyl-5-(5-methylbutyl)-1,3-diazinane-2,4,6-trione
c) 5-ethyl-5-(3-methylbutyl)-1,3-diazinane-2,4-dione
d) 3-ethyl-5-(5-methylbutyl)-1,3-diazinane-2,4-dione
Q.2 Which amongst the following statements is/are incorrect related to the SAR of Amobarbital?
I. Tri-keto form is least stable in aqueous solution.
II. 4,6-dialcoholic tautomeric forms are most stable in aqueous solution.
III. 5,5-disubstituted barbituric acid is the prime requirement for the barbituares to be sedative hypnotics.
IV. Esterification of either of the 1,3-diazine nitrogens decreases hypnotic activity.
a) III, IV
b) I, III, IV
c) I, III
d) I, II
Q.3 The correct order for the synthesis of drug amobarbital from diethyl malonate can be?
I. Reaction with ethyl bromide
II. Reaction with sodium ethoxide
III. Condensation with urea
IV. Reaction with 1-bromo-3-methylbutane
a) II – IV- III – I
b) II – I – IV – III
c) IV- II – I – III
d) III – II – I – IV
Q.4 Side effects of drug Amobarbital is/are?
a) Nervousness
b) Hallucinations
c) Bradycardia
d) All of the above
Q.5 Match the following drugs with their correct octanol/water partition coefficient-
i. Amobarbital | A. 2.12 |
ii.Nitrazepam | B. 2.25 |
iii. Triazolam | C. 2.07 |
iv. Clobazam | D. 2.42 |
a) i-A, ii-C, iii-B, iv-D
b) i-D, ii-C, iii-A, iv-B
c) i-A, ii-B, iii-C, iv-D
d) i-C, ii-B, iii-D, iv-A
Q.6 An example of drug from class barbiturate sedative-hypnotic?
a) Oxazepam
b) Amobarbital
c) Zolpidem
d) Chlordiazepoxide
Q.7 The type of ring system found in structure of amobarbital?
a) Diazepine
b) Benzene
c) Pyrimidine
d) Purine
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1-a
2-d
3-b
4-d
5-d
6-b
7-c
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