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]]>2-Acetoxybenzoic acid
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 180.16 g/mol |
2 | Physical appearance | White crystalline powder |
3 | Melting point | 140°C |
4 | Solubility | 1 g soluble in 300 ml of water. |
5 | Octanol/water partition coefficient | 1.18 |
6 | Presence of ring | Phenyl |
7 | Number of chiral centers | Not present |
SAR for salicylates can be summarized as follows:
Aspirin can be synthesised by the acetylation of the salicylic acid by acetic anhydride or acetyl chloride. [2]
Aspirin is used for:
Side Effects
Side effects Aspirin are:
Q.1 “2-acetoxybenzoic acid” is the IUPAC nomenclature of which drug?
a) Aspirin
b) Paracetamol
c) Loperamide
d) Zolpidem
Q.2 Correct melting point of the drug Aspirin is?
a) 124°C
b) 321°C
c) 140°C
d) 26°C
Q.3 Match the following with correct classifications of the drugs.
i. Loperamide | A. Antidiarrheal agent |
ii. Aspirin | B. ß-blockers |
iii. Methoxyflurane | C. NSAID |
iv. Metoprolol | D. Anticonvulsant drug |
a) i-A, ii-C, iii-D, iv-B
b) i-C, ii-A, iii-B, iv-D
c) i-D, ii-C, iii-A, iv-B
d) i-A, ii-D, iii-C, iv-B
Q.4 Mechanism of action of drug Aspirin includes?
I. Binding irreversibly with COX-2 enzyme.
II. Binding with COX-1 enzyme.
III. Prevention of conversion of arachidonic acid to thromboxane
IV. Prevention of Thromboembolism
a) II, III, IV
b) II, IV
c) I, III, IV
d) I, II
Q.5 Correct sequence for True and False for the given statements related with the SAR of Salicylates drugs?
a) FFTT
b) TFTF
c) TFFT
d) TTFT
Q.6 Acetylation of salicylic acid leads to formation of which drug?
a) Tolazoline
b) Aspirin
c) Isoflurane
d) Orphenadrine
Q.7 The drug Aspirin is used for?
a) Reducing fever
b) Prevention of blood clot
c) Blood thinner
d) All of the above
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1-a
2-c
3-a
4-a
5-d
6-b
7-d
The post ASPIRIN Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
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