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]]>(RS)-(8-Methyl-8-azabicyclo[3.2.1]oct-3-yl) 3-hydroxy-2-phenylpropanoate.
Atropine is a acetylcholine antagonist-muscarinic antagonist.
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 289.4 g/mol |
2 | Physical appearance | Rhombic or orthorhombic prisms. |
3 | Melting point | 118.5°C. |
4 | Solubility | 0.01M in water |
5 | Octanol/water partition coefficient | 1.83 |
6 | Presence of ring | Cycloalkane and benzene |
7 | Number of chiral centers | 4 |
Atropine binds with muscarinic acetylcholine receptors and inhibits them. Thus, they produce a wide range of anticholinergic effects. [1]
Tropine and tropic acid reacts together to give atropine.
Atropine is used for:
Side Effects
Side effects of atropine are:
Some uncommon side effects are:
Q.1 What can be the correct IUPAC nomenclature of Atropine?
a) (RS)-1-(1-methylethylamino)-3-(1-naphthyloxy)propan-2-ol.
b) [8-methyl-8-(1-methylethyl)- 8-azoniabicyclo[3.2.1] oct-3-yl] 3-hydroxy-2-phenyl-propanoate
c) (RS)-(8-Methyl-8-azabicyclo[3.2.1]oct-3-yl) 3-hydroxy-2-phenylpropanoate
d) 2-[(Aminocarbonyl)oxy]-N,N,N-trimethylethanaminium chloride.
Q.2 Which amongst the following statements is/are incorrect related to the SAR of Atropine?
I. X can also be either oxygen or absent completely.
II. The N substituent can be quaternary ammonium salt or tertiary amine or both with different alkyl groups.
III. Minimum potency obtained when the distance between the ring substituted carbons is 2 carbon units.
a) III
b) I
c) II, I
d) II, III
Q.3 The interaction of Tropine and tropic acid produces?
a) Atropin
b) Carbachol
c) Procyclidine
d) Doxacurium
Q.4 Side effects of drug Atropine is/are?
a) Pounding heart beats
b) Blurred vision
c) Dryness in mouth
d) All of the above
Q.5 Match the following drugs with correct number of chiral carbons they are having.
i. Propranolol | A. 1 |
ii. Carbachol | B. 4 |
iii. Ipratropium bromide | C. 0 |
iv. Atropine | D. 5 |
a) i-A, ii-C, iii-B, iv-D
b) i-D, ii-,B iii-A, iv-C
c) i-B, ii-D, iii-A, iv-C
d) i-A, ii-C, iii-D, iv-B
Q.6 An example of drug from class Acetylcholine Antagonist (muscarinic antagonist) is?
a) Donepezil
b) Carbachol
c) Atropin
d) Paraoxin
Q.7 The type of ring system found in Atropin?
a) Benzene
b) Napthalene
c) Imidazole
d) None of the above
1-c
2-a
3-a
4-d
5-d
6-c
7-a
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