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]]>(3-endo)-3-(Diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane
Benztropine is an acetylcholine antagonist. It is a muscarinic antagonist.
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 307.4 g/mol |
2 | Physical appearance | White to off-white powder |
3 | Melting point | 135°C. |
4 | Solubility | 24.9mg/L in water |
5 | Octanol/water partition coefficient | 4.27 |
6 | Presence of ring | Bicycle ring and benzene rings |
7 | Number of chiral centers | 3 |
Benztropine inhibits uptake of dopamine and thus, helps in reducing the symptoms of Parkinson’s diseases.
Structure Activity Relationship
i. Diphenylmethane undergoes bromination to form bromodiphenylmethane.
ii. It is followed by condensation with tropine and purification to get benztropin.
Benztropine is used for:
Side effects of benztropine are:
Q.1 Match the following with correct SAR of the drug benztropine-
i. When X is an ester | A. Maximum potency |
ii. Distance between the ring substituted carbons is 2 carbon unit | B.Minimum potency |
C. Least potent derivative | |
D. Most potent derivative |
a) i-A, ii-D
b) i-A, ii-C
c) i-B, ii-C
d) i-C, ii-D
Q.2 Correct sequence for the True/False for correct IUPAC names of the drug can be?
a) TFTF
b) TTFF
c) FFTT
d) TTFT
Q.3 Number of chiral carbons present in the structure of Benztropine?
a) 0
b) 1
c) 2
d) 3
Q.4 Benztropine helps in reducing the symptoms of Parkinson’s diseases by?
a) Stimulating the uptake of dopamine
b) Binding with GABA receptor complex
c) Inhibiting the uptake of dopamine
d) Both a) and b)
Q.5 Which amongst the following is a therapeutic use of drug benztropine?
a) Treatment of Insomnia
b) Treatment of Alzheimer’s disease
c) Treatment of Parkinson’s disease
d) Treatment of Asthma
Q.6 Which of the following drug and their classification are correct?
I. Benztropine: acetylcholine antagonist
II. Fesoterodine: Nitrogen mustard
III. Flurazepam: benzodiazepine sedative hypnotic
IV. Midazolam: Acetylcholine Nicotinic receptor antagonist
a) I, III
b) I, III, IV
c) II, IV
d) I, II, III, IV
Q.7 When bromodiphenyl methane undergoes condensation with tropine, the drug formed is?
a) Midazolam
b) Fesoterodine
c) Benztropine
d) Methysergide
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1-a
2-b
3-d
4-c
5-c
6-a
7-c
The post BENZTROPINE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
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