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]]>(RS)-1-{4-[(2-Isopropoxyethoxy)methyl]phenoxy}-3-(isopropylamino)propan-2-ol.
Bisoprolol is a cardioselective ß1-adrenergic antagonist
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 325.4 g/mol |
2 | Physical appearance | Solid |
3 | Melting point | 100°C |
4 | Solubility | 0.0707 mg/ml in water |
5 | Octanol/water partition coefficient | 2.2 |
6 | Presence of ring | Benzene |
7 | Number of chiral centers | 1 |
i. Isopropylaminopropanediol reacts with dimethylcarbonate to produce oxalidinone sulphonate.
ii. Oxalidinone sulphonate reacts with 4-hydroxybenzaldehyde to give oxalidinone benzaldehyde.
iii. Oxaldinone benzaldehyde is converted into oxalidinone benzylalcohol.
iv. Oxalidinone benzylalcohol is reacted with isopropyl oxitol to form bisoprolol.
Bisoprolol is used for treatment of:
Side effects of Bisoprolol are:
Q.1 “(RS)-1-{4-[(2-Isopropoxyethoxy)methyl]phenoxy}-3-(isopropylamino)propan-2-ol” is the IUPAC nomenclature of which drug?
a) Bisprolol
b) Methysergide
c) Phentolamine
d) Carvediol
Q.2 Melting point of Bisoprolol is?
a) 250°C
b) 250°C
c) 100°C
d) 225°C
Q.3 Match the following with correct classifications of the drugs.
i. Bisoprolol | A. Ergot alkaloid |
ii. Methysergide | B. ß2-adrenergic agonist |
iii. Isoproterenol | C. ß1-adrenergic antagonist |
iv. Dobutamine | D. ß1-adrenergic agonist |
a) i-B, ii-C, iii-A, iv-D
b) i-D, ii-A, iii-C, iv-B
c) i-C, ii-A, iii-D, iv-B
d) i-C, ii-A, iii-B, iv-D
Q.4 Correct steps for the mechanism of action of the drug Bisoprolol
I. Blocking of ß1-adrenergic receptors
II. Blocking of ß2-adrenergic receptors
III. Reduction in the cardiac output
IV. Lowering of blood pressure
a) I – III – IV
b) II – III – IV
c) III – I – IV
d) III – II – IV
Q.5 Correct sequence for True and False for the given statements related with the SAR of drug bisoprolol?
a) TFFT
b)FFTT
c) FTTF
d) TTTF
Q.6 Oxalidinone benzylalcohol is reacted with isopropyl oxitol to form?
a) Amphetamine
b) Metaraminol
c) Bisoprolol
d)Oxymetazoline
Q.7 The drug Bisoprolol is mainly used for?
a) Treatment of high blood pressure
b) Treatment of hypotension
c) Increasing the libido
d) Prevention of gonorrhea
1-a
2-c
3-d
4-a
5-c
6-c
7-a
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