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]]>IUPAC nomenclature
Butane-1,4-diyl dimethanesulfonate
Busulfan falls under the category of alkyl sulfonate alkalyting agents.
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 246.3 g/mol |
2 | Appearance | White crystalline solid |
3 | Melting point | 114-118°C |
4 | Solubility | 69000mg per litre at NTP |
5 | Octanol water partition coefficient | -0.52 |
6 | Presence of ring | No ring system |
1,4-butanediol is reacted with methansulphonyl chloride to produce busulfan.
Q.1 Butane-1,4-diyl dimethanesulfonate is the IUPAC nomenclature of which drug?
a) Thiotepa
b) Busulfan
c) Ifosfamide
d) Mechlorethamine
Q.2 Predict the incorrect statement related to Busulfan
a) It has an aziridine ring system
b) It is an example of class alkylating agents
c) It leads to apoptosis of the cell
d) Most common side effect is low blood count
Q.3 Match the following with respect to the drug busulfan
i. introduction of substituted phenyl group | A. local and faster action of the drug |
ii. binding of drug with amino group | B. increase the oral route availability |
iii. introduction of aromatic ring | C. increase the stability of the drug |
iv. introduction of benzimidazol ring | D. increase oral route availability |
a) i-C, ii-A, iii-D, iv-B
b) i-B, ii-D, iii-A, iv-C
c) i-D, ii-C, iii-A, iv-B
d) i-D, ii-B, iii- C, iv-A
Q.4 Which amongst the following drugs shows its effect through alkylation of DNA strand?
a) Vincristine
b) Vinblastine
c) Busulfan
d) Flutamide
Q.5 Busulfan drug belongs to which class?
a) Nitrogen mustard alkalyting agent
b)Triazine alkalyting agent
c) Ethylinimine alkalyting agent
d) Nitrosoureas alkalyting agent
Q.6 Which of the following is not a side effect of Busulfan?
Q.7 Which among the following drugs is having least number of ring system in its structure-
a) Melphalan
b) Morphine
c) Busulfan
d) Cyclophosphamide
1-b
2-a
3-d
4-c
5-c
6-d
7-c
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