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]]>5-butan-2-yl-5-ethyl-1,3-diazinane-2,4,6-trione.
Butabarbital is a barbiturate sedative-hypnotic.
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 212.25 g/mol |
2 | Physical appearance | Fine white crystalline powder |
3 | Melting point | 166.5°C |
4 | Octanol/water partition coefficient | 1.65 |
5 | Solubility | 294 mg/L in water |
6 | Presence of ring | Pyrimidine |
7 | Number of chiral centers | 1 |
Diethyl 2-sec-butyl-2-ethylmalonate reacts with urea in presence of sodium ethoxide to give butabarbital.
Butabarbital is used for:
Side effects of Butabarbital are:
Q.1 Match the following with correct SAR of the drug butabarbital-
i. Triketoform | A. Increased lipophillicity |
ii. 4,6-dialcoholic form | B. Most stable in aqueous form |
iii. Esterifiation of either of diazine nitrogen atom | C. Decreased hypnotic activity |
iv. Modification of the 2nd-position oxygen of the barbiturate backbone withv sulfur atom | D. Least stable in aqueous form |
a) i-D, ii-C, iii-A, iv-B
b) i-D, ii-B, iii-A, iv-C
c) i-B, ii-D, iii-C, iv-A
d) i-A, ii-B, iii-D, iv-C
Q.2 Correct sequence for the True/False for correct IUPAC names of the drug can be?
a) TFTF
b) TTFF
c) FTTF
d) FFFF
Q.3 Physical appearance of butabarbital is?
a) Red-brown crystalline powder
b) Fine white crystalline powder
c) Green granular form
d) None of these
Q.4 Butabarbital shows its mechanism of action through biding with which receptor?
a) GABAA
b) Acetylcholine muscarinic receptor
c) Acetylcholine nicotinic receptor
d) None of the above
Q.5 Which amongst the following is a therapeutic use of drug Butabarbital?
a) Sedative before surgery
b) Treatment of anxiety
c) Treatment of cancer
d) All of the above
Q.6 Which of the following drug and their classification are correct?
I. Butabarbital: Barbiturate sedative-hypnotic
II. Diazepam: Benzazepenes
III. Thiothixene: Benzodiazepenes
IV. Haloperidole: Benzisothiazole
a) I
b) I, III
c) II, IV
d) II, III
Q.7 Butabarbital can be synthesized from reaction of?
a) Diethyl 2-sec-butyl-2-ethylmalonate with Urea
b) Diethyl 2-sec-butyl-2-ethylmalonate with Hydrazine
c) Diethyl 2-sec-butyl-2-ethylmalonate with Thiourea
d) Diethyl 2-sec-butyl-2-ethylmalonate with Methylhalide
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1-c
2-b
3-b
4-a
5-a
6-a
7-a
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