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]]>2-[(4-Chlorophenyl)-pyridin-2-yl-methoxy]-N,N-dimethyl-ethanamine
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 290.79 g/mol |
2 | Physical appearance | Solid |
3 | Melting point | <25oC |
4 | Solubility | 2.28e-01 g/L |
5 | Octanol/water partition coefficient | 2.6 |
6 | Presence of ring | Phenyl , pyridine |
7 | Number of chiral centers | 1 |
i. The drug binds with Histamine H1 receptor and produces antagonistic effects.
ii. This results in blockage of action of endogenous histamine
iii. Temporary relief of negative symptoms produced due to histamine
iv. Antiemetic effect is due to antagonistic effects on muscarinic receptors.
Structure activity of ethanolamine ethers can be summarized as:
i. 4-chloropenyl magnesiumbromide is reacted with picolinaldehyde to give (4-chlorophenyl)(pyridin-2-yl)methanol.
ii. (4-chlorophenyl)(pyridin-2-yl)methanol is reacted with 2-chloro-N,N-dimethylethanamine to give carbinoxamine
Carbinoxamine is used for treatment of:
Side Effects
Side effects of carbinoxamine are:
Q.1 “2-[(4-Chlorophenyl)-pyridin-2-yl-methoxy]-N,N-dimethyl-ethanamine” is the IUPAC nomenclature of which drug?
a) Carbinoxamine
b) Edrophonium
c) Auranofin
d) Tenoxicam
Q.2 Molecular weight of Carbinoxamine is?
a) 199.3 gm/mol
b) 234.2 gm/mo
c) 290.79 gm/mol
d) 134.32 gm/mol
Q.3 Match the following with correct classifications of the drugs.
i. Carbinoxamine | A. Ethanolamine ether antihistamine drug |
ii. Propranolol | B. Benzodiazepine anticonvulsants |
iii. Secobarbital | C.Barbiturates |
iv. Clonazepam | D. Beta-adrenergic blockers |
a. i-A, ii-C, iii-B, iv-D
b. i-C, ii-D, iii-A, iv-B
c. i-D, ii-,B iii-A, iv-C
d. i-A, ii-D, iii-C, iv-B
Q.4 Which of the following mechanisms are involved for the action of Carbinoxamine drug?
I. Produces antagonistic effects on muscarinic receptors
II. Produces antagonistic effects on H1 receptors
III. There is blockage of action of endogenous histamine
IV. Drug also produces beta blocking actions.
a) I, IV
b) II, III
c) I, III, IV
d) I, II, III
Q.5 Correct sequence for True and False for the given statements related with the SAR of class ethanolamine ethers antihistamines can be?
a) TFFT
b) TFTF
c) TTTT
d) FTFF
Q.6 (4-chlorophenyl)(pyridin-2-yl)methanol is reacted with 2-chloro-N,N-dimethylethanamine to give which drug?
a) Dimenhydrinate
b) Carbinoxamine
c) Diphenhydramine
d) Chlordiphenhydramine
Q.7 The drug carbinoxamine is mainly used for?
a) Treatment of sneezing
b) Treatment of watery eyes
c) Treatment of runny nose
d) All of the above
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1-a
2-c
3-d
4-b
5-a
6-b
7-d
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