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]]>3‑(2‑Hydroxy-2,2‑diphenylacetoxy)spiro[bicyclo[3.2.1]octane-8,1’‑pyrrolidin]-1’‑ium chloride.
Trospium is an antispasmodic agent.
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 428 g/mol |
2 | Physical appearance | Colorless to slightly yellow, fine crystalline solid. |
3 | Melting point | 255-258°C. |
4 | Solubility | 1 gm/2ml in water |
5 | Presence of ring | Benzene and other ring structure present |
6 | Number of chiral centers | 3 |
i. (1) undergoes chlorination to prouduce (2).
ii. (2) reacts with (3) in presence of pyridine and chloroform to give (4).
iii. (4) in presence of K2CO3 and water produces (5).
iv. (5) undergoes reduction to give (6).
v. (6) reacts with (7) to produce trospium chloride.
Trospium chloride is used for:
Side effects of trospium chloride are:
Q.1 3‑(2‑Hydroxy-2,2‑diphenylacetoxy)spiro[bicyclo[3.2.1]octane-8,1′‑pyrrolidin]-1′‑ium chloride” is the IUPAC nomenclature of which drug?
a) Acetylcholine
b) Cevimeline
c) Trospium chloride
d) Carvedilol
Q.2 Molecular weight of Trospium chloride is?
a) 146.21 gm/mol
b) 199.32 gm/mol
c) 428 gm/mol
d) 406.5 gm/mol
Q.3 Match the following with correct classifications of the drugs.
i. Cavedilol | A. Antispasmodic agent |
ii. Trospium chloride | B. Ach mimetic |
iii. Cevimeline | C. Mixed α/ß blocker |
iv. Metocurine | D. Nicotinic antagonist |
a) i-,B ii-,C iii-A, iv-D
b) i-D, ii-A, iii-C, iv-B
c) i-C, ii-A, iii-B, iv-D
d) i-B, ii-A, iii-C, iv-A
Q.4 Trospium chloride mechanism of action depends on?
a) Antagonism of acetylcholine for muscarinic receptors
b) Agonism of acetylcholine for muscarinic receptors
c) Antagonism of acetylcholine for nicotinic receptors
d) Agonism of acetylcholine for nicotinic receptors
Q.5 Correct sequence for True and False for the given statements related with the SAR of drug trospium chloride.
a) TTFF
b) FTFT
c) TTTT
d) FFTF
Q.6 Number of chiral centers present in trospium chloride?
a) 1
b) 2
c) 3
d) 4
Q.7 The drug trospium chloride is mainly used for?
a) Symptoms of dry mouth
b) Alzhiemer’s disease
c) Treatment of overreactive bladder
d) None of the above
1-c
2-c
3-c
4-a
5-c
6-c
7-c
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