The post PREDNISOLONE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
]]>(11β)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione.
Prednisolone falls under the category of glucocorticoids. [1]
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 360.4 g/mol |
2 | Appearance | White crystalline powder. Prednislolone have one sesquihydrate and two polymorphic forms (I & II). Form I is present in the monoclinic space while the other two forms exist in orthorhombic form. |
3 | Melting point | 235°C |
4 | Solubility | 223 mg per liter in water |
5 | Octanol/water partition coefficient | 1.62 |
6 | Presence of ring | Phenanthrene and cyclopentane |
7 | Number of chiral centers | 7 |
i. 21-acetoxy-11β,17α-dihydroxy-5α-pregnan-3,20-dione undergoes dibromination at positions C-2 and C-4.
ii. The formed dibromide is dehydrobrominated by heating it in collidine to obtain prednisolone as an acetate at position C-21.
iii. Hydrolyzing the latter product gives Prednisolone.
Prednisolone is given for the treatment of
Drug is also used for the stimulation of the appetite in cancer patients.
Q.1 ‘(11β)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione’ is the IUPAC nomenclature of which drug?
a) Imatinib
b) Carmustine
c) Thiotepa
d) Prednisolone
Q.2 Predict the incorrect statement related to the therapeutic uses of drug Prednisolone-
a) It is given to stimulate the appetite of the patient
b) It is given for the treatment of cancers
c) It is given to induce vomiting in patients
d) It is given for the treatment of autoimmune disorders
Q.3 Match the following with respect to the SAR of drug prednisolone-
i. Introduction of 17-alpha-hydroxy group | A. Increases the activity of drug |
ii. Double bond at C-1 position | B. Decreases the activity of drug |
C. Increases the activity of drug | |
D. Decreases the activity of drug |
a) i-A, ii-C
b) i-A, ii-D
c) i-B, ii-C
d) i-B, ii-D
Q.4 Which amongst the following drugs shows its effect through inhibition of phospholipase A2?
a) Prednisolone
b) Imatinib
c) Mechlorethamine
d) Flutamide
Q.5 Prednisolone drug belongs to which class?
a) Estrogen antineoplastic drug
b) Glucocorticoid antineoplastic drug
c) Progestin antineoplastic drug
d) Antiandrogen antineoplastic drug
Q.6 Which of the following is NOT a side effect of Prednisolone?
a) Loss of appetite
b) Muscle weakness
c) Insomia
d) Increases blood sugar level
Q.7 How many ring are present in the structure of Prednisolone?
a) 1
b) 2
c) 3
d) 4
1-d
2-c
3-a
4-a
5-b
6-a
7-d
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