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]]>1-cyano-2-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]guanidine
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 252.34g/mol |
2 | Physical appearance | White crystalline solid |
3 | Melting point | 142oC |
4 | Solubility | Soluble in alcohol |
5 | Octanol/water partition coefficient | 0.4 |
5 | Presence of ring | Imidazole |
6 | Number of chiral centers | Not present |
General structure activity of H2-antihistamines antiulcer drugs can be summarized as:
i. Reaction of 2-chloroacetoacetic ether with 2 mole of formamide to get 4-carbethoxy-5-methylimidazole.
ii. Reducing the carbethoxy group by sodium in liquid ammonia produces 4-hydroxymethyl-5-methylimidazole.
iii. Hydrochloride of the resulting alcohol is reacted with 2-mercaptoethylamine hydrochloride to give 4-(2-aminomethyl)-thiomethyl-5-methylimidazole dihydrochloride.
iv. On reacting the above formed compound with –cyanimido-S,S-methylamine produces cimetidine. [1]
Cimetidine is used for treatment of:
Side effects of Cimetidine are:
Q.1 Mechanism of action of Cimetidine drug includes?
a) Binds with H2 receptor
b) Binds with H1 receptors
c) Antagonistic effects at H1 receptor for histamine
d) Agonist effects H1 receptor for Histamine
Q.2 Medicinal use of drug Cimetidine is/are?
a) Stomach ulcers
b) Acid indigestion
c) Erosive esophagitis
d) All of the above
Q.3 The type of ring which should be maintained for affinity at H2 receptor site in cimetidine ring is?
a) Piperazine
b) Pyridine
c) Cyclohexane
d) Imidazole
Q.4 Number of chiral carbons present in the structure of Cimetidine is?
a) 0
b) 1
c) 2
d) 3
Q.5 Correct sequence for the True/False for the physiochemical properties of the drug cimetidine can be?
a) TTT
b) TFT
c) FFT
d) TFF
Q.6 Correct statements for the IUPAC nomenclatures of the drugs are?
I. Cimetidine: 1-cyano-2-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]guanidine
II. Rabeprazol: (RS)-2-([4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methylsulfinyl)-1H-benzo[d]imidazole.
III. Amiodarone: Ethyl-(3-hydroxyphenyl)-dimethylazanium
IV. Clonidine: 4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-ylthieno[2,3-e]thiazine-3-carboxamide
a) I, II
b) III, IV
c) IV
d) I, II, III, IV
Q.7 Match the following drugs with their correct classifications-
i. Dimenhydrinate | A. H2-antagonist |
ii. Cimetidine | B.Vasodilator |
iii. Thioguanine | C. Antimetabolite |
iv. Isosorbide | D. H1-receptor antihistamine |
a) i-A, ii-C, iii-D, iv-B
b) i-D, ii-A, iii-C, iv-B
c) i-D, ii-B, iii-A, iv-C
d) i-B, ii-D, iii-A, iv-C
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1-a
2-d
3-d
4-a
5-b
6-a
7-b
The post CIMETIDINE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
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