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]]>1-benzhydryl-4-methyl-piperazine
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 266.4 g/mol |
2 | Physical appearance | White or creamy white crystalline powder |
3 | Melting point | 105.5oC |
4 | Solubility | Soluble in alcohol and chloroform; slightly soluble in water; freely soluble in ether |
5 | Octanol/water partition coefficient | 3 |
5 | Presence of ring | Piperazine, phenyl |
6 | Number of chiral centers | Not present |
Structure activity of piperizine antihistamines can be summarized as:
Alkylation of 1-methylpiperazine with benzhydrylbromide gives cyclizine. [1]
Cyclizine is used for treatment of:
Side effects of cyclizine are:
Q.1 Correct statements from the following related with the physicochemical properties of drug cyclizine are?
I. Molecular weight: 266.4 gm/mol
II. Appearance: White or creamy white crystalline powder
III. Melting Point: 105.5oC
IV. Solubility: Soluble in alcohol
a) I, II, IV
b) I, III, IV
c) II, IV
d) I, II, III, IV
Q.2 Match the following of the drugs with their correct IUPAC names.
i. Cyclizine | A. (RS)-6-(Difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]-1H-benzo[d]imidazole |
ii. Lansoprazol | B. 2-[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl]-1H-benzimidazole |
iii. Famotidine | C. 3-[({2-[(diaminomethylidene)amino]-1,3-thiazol-4-yl}methyl)sulfanyl]-N-sulfamoylpropanimidamide |
iv. Pentoprazole | D. 1-benzhydryl-4-methyl-piperazine |
a) i-D, ii-B, iii-C, iv-A
b) i-A, ii-B, iii-D, iv-C
c) i-B, ii-C, iii-A, iv-D
d) i-A, ii-C, iii-D, iv-B
Q.3 Cyclizine has actions on?
I. Vomiting center
II. Cholinergic receptors
III. Muscarinic receptors
IV. Nicotinic receptors
a) I, III
b) I, IV
c) I, II, III
d) I
Q.4 Correct sequence for True/false for the classification of the drug can be?
a) TFTF
b) TTTT
c) FFTF
d) TFFT
Q.5 Piperizine antihistamine drugs are derivatives of?
a) Ethylene diamine
b) Piperidine
c) Benzodiazepine
d) Phenothiazine
Q.6 Type of rings present in the structure of cyclizine?
I. Pyridine
II. Piperazine
III. Phenyl
IV. Benzodiazepine
a) I, IV
b) I
c) II, III
d) II
Q.7 Side effect of drug Cyclizine is/are?
a) Difficulty urination
b) Loss of coordination
c) Nausea
d) All of the above
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ANSWERS
1-d
2-a
3-c
4-b
5-a
6-c
7-d
REFERENCES
[1] Vardanyan R, Hruby V. Synthesis of essential drugs. Elsevier; 2006 Mar 10.
The post CYCLIZINE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
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