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]]>4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 287.4 g/mol |
2 | Physical appearance | Crystals from dilute ethanol |
3 | Melting point | 112.8oC |
4 | Solubility | Soluble |
5 | Octanol/water partition coefficient | 4.69 |
5 | Presence of ring | Piperidine ring |
6 | Number of chiral centers | Not present |
General structure activity of first generation H1-receptors antagonist can be summarized as:
i. Reaction of 1-methyl-4-magnesiumchloropiperidine with 5H-dibeno[a,d]cyclohepten-5-one to form a carbinol.
ii. The formed carbinol is dehydrated under acidic condition to give cyproheptadine. [1]
Cyproheptadine is used for treatment of:
Side effects of cyproheptadine are:
Q.1 Match the following with correct SAR of the first generation H1 receptor antihistamine drugs:
i. Terminal nitrogen atom should be | A. Secondary in nature |
ii. Ethylene chain gives | B. Tertiary in nature |
C. Minimum activity | |
D. Maximum activity |
a) i-A, ii-C
b) i-A, ii-D
c) i-B, ii-C
d) i-B, ii-D
Q.2 Correct sequence for the True/False for correct IUPAC names of the drug can be?
a) TFFT
b)TFFF
c) TTTT
d) FFFT
Q.3 Molecular weight of Cyproheptadine is?
a) 245.3 gm/mol
b) 452.0 gm/mol
c) 287.4 gm/mol
d) 46.9 gm/mol
Q.4 Along with antihistaminic property, Cyproheptadine also has?
a) Anti-metabolic activity
b) Anti-neoplastic actvity
c) Anti-serotonergic activity
d) Anti-hyperlipidemic activity
Q.5 Which amongst the following is not a therapeutic use of drug Cyproheptadine?
a) Chronic urticaria
b) Bronchial asthma attacks
c) Itching
d) Anesthetics
Q.6 Which of the following drug and their classification are correct?
I. Cyproheptadine: Proton pump inhibitor
II. Cocaine: Local anesthetics
III. Rabeprazole: Proton pump inhibitor
IV. Amyl nitrite: Vasodilator
a) I, III
b) II, III, IV
c) III, IV
d) I, II, III
Q.7 Number of chiral carbons present in the structure of Cyproheptadine?
a) 1
b) 3
c) 4
d) 0
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1-d
2-b
3-c
4-c
5-d
6-b
7-d
The post CYPROHEPTIDINE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
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