The post DEXLANSOPRAZOLE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
]]>(R)-(+)-2-([3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl)-1H-benzo[d]imidazole
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 369.4 g/mol |
2 | Physical appearance | White to brownish-white crystalline powder |
3 | Melting point | 140oC |
4 | Solubility | 0.21 mg/ml |
5 | Octanol/water partition coefficient | 2.38 |
5 | Presence of ring | Pyridine. Benzimidazole |
6 | Number of chiral centers | Not present |
Structure Activity Relationship
General structure activity of Heteroaryl- and heterocyclyl-substituted imidazo[1,2-a]Pyridine derivatives acting as acid pump antagonists can be summarized as:
TAP’s group synthesized the Dexlansoprazole through the following scheme: [2]
Dexlansoprazole is used for treatment of:
Side effects of Dexlansoprazole are:
Q.1 Mechanism of action of Dexlansoprazole drug includes?
a) Protonation into sulphenamide
b) Conversion into hydroxyzine
c) Vasoconstriction
d) Agonist effects H1 receptor for Histamine
Q.2 Medicinal use of drug Dexlansoprazole is/are?
a) Stomach ulcers
b) Watery eyes
c) Sneezing
d) Hives
Q.3 Select the correct option from below related with the General structure activity of Heteroaryl- and heterocyclyl-substituted imidazo[1,2-a]Pyridine derivatives acting as acid pump antagonists-
a) The inhibitory property of drugs depends on hydrophobic group substituted at the left side ortho-position of the phenyl ring.
b) Increase in hydrophobic value decreases the activity.
c) Increasing the GTCI value increases the activity.
d) All of the above
Q.4 Number of chiral carbons present in the structure of Dexlansoprazole is?
a) 0
b) 1
c) 2
d) 3
Q.5 Correct sequence for the True/False for the physiochemical properties of the drug dexlansoprazole can be?
a) TTT
b) TFT
c) FFT
d) TFF
Q.6 Correct statements for the IUPAC nomenclatures of the drugs are?
I. Dexlansorazole: 2-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]guanidine
II. Loxapine: (3-methylpyridin-2-yl]methylsulfinyl)-1H-benzo[d]imidazole.
III. Gluthethmide: 4-Chlorophenyl)phenylmethyl-1-piperazinyl]ethoxy]acetic acid
IV. Tolazoline: 2-Benzyl-4,5-dihydro-1H-imidazole
a) I, II
b) III, IV
c) IV
d) I, II, III, IV
Q.7 Match the following drugs with their correct classifications-
i. Dexlansoprazole | A. Proton pump inhibitor |
ii. Ibuprofen | B. Sedative-hypnotic |
iii. Naloxone | C. Anti-inflammatory |
iv. Chlordiazepoxide | D. Narcotic antagonist |
a) i-A, ii-C, iii-D, iv-B
b) i-D, ii-A, iii-C, iv-B
c) i-D, ii-B, iii-A, iv-C
d) i-B, ii-D, iii-A, iv-C
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1-a
2-a
3-a
4-a
5-c
6-c
7-a
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