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]]>2-(diphenylmethoxy)-N,N-dimethylethanamine
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 255.35 g/mol |
2 | Physical appearance | Solid |
3 | Melting point | 168oC |
4 | Solubility | 3060 mg/L |
5 | Octanol/water partition coefficient | 3.27 |
6 | Presence of ring | Phenyl ring |
7 | Number of chiral centers | Not present |
Structure activity of ethanolamine ethers antihistamines can be summarized as:
Diphenhydramine is used for treatment of:
Side effects of diphenhydramine are:
Q.1 “2-(diphenylmethoxy)-N,N-dimethylethanamine” is the IUPAC nomenclature of which drug?
a) Diphenhydramine
b) Chlorpheniramine
c) Terbutaline
d) Cetrizine
Q.2 Molecular weight of Diphenhydramine is?
a) 300.23 gm/mol
b) 255.35 gm/mo
c) 190.0 gm/mol
d) 134.32 gm/mol
Q.3 Match the following with correct classifications of the drugs.
i. Diphenhydramine | A. Ethanolamine ether antihistamine drug |
ii. Dactinomycin | B. H2-antagonist |
iii. Clofibrate | C. Anti-hyperlipidemic agent |
iv. Cimetidine | D. Anti-biotics anti-neoplastic drug |
a. i-A, ii-C, iii-B, iv-D
b. i-C, ii-D, iii-A, iv-B
c. i-D, ii-,B iii-A, iv-C
d. i-A, ii-D, iii-C, iv-B
Q.4 Which of the following mechanisms are involved for the action of diphenhydramine drug?
I. Inverse agonist for H1 receptors
II. Inverse agonist for H2 receptors
III. Activity as an intracellular sodium channel blocker
IV. Competitively antagonizing the action of muscarinic acetylcholine receptors.
a) I, IV
b) II, III, IV
c) I, III, IV
d) I, II, III
Q.5 Correct sequence for True and False for the given statements related with the SAR of class ethanolamine ethers antihistamines can be?
a) TTFF
b) TFTF
c) TTTT
d) FTFF
Q.6 Diphenhydramine can be synthesized by the reaction of benzhydrylbromide with?
a) 2-dimethylaminoethanol
b) p-aminobenzoic acid
c) Benzoic acid
d) Butanoic acid
Q.7 The drug diphenhydramine is mainly used for?
a) Treatment of sneezing
b) Treatment of watery eyes
c) Treatment of motion sickness
d) All of the above
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1-a
2-b
3-d
4-c
5-c
6-a
7-d
The post DIPHENHYYDRAMINE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
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