The post DOXYLAMINE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
]]>(RS)-N,N-dimethyl-2-(1-phenyl-1-pyridin-2-yl-ethoxy)-ethanamine
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 270.37 g/mol |
2 | Physical appearance | Clear colorless liquid |
3 | Melting point | <25oC |
4 | Solubility | Soluble in acids |
5 | Octanol/water partition coefficient | 2.15 |
6 | Presence of ring | Pyridine, phenyl |
7 | Number of chiral centers | 1 |
Structure activity of ethanolamine ethers can be summarized as:
i. Reaction of 2-acetylpyridine and bromobenzene in presence of magnesium turning, tetrahydrofuran and toluene solvent to produce 2-pyridylphenylmethyl carbinol HCl.
ii. The above formed compound is reacted with 2-dimethylaminoethyl chloride hydrochloride in presence of potassium hydroxide and toluene solvent to get doxylamine.
iii. To produce doxylamine succinate, the last formed compound is treated with succinic acid in acetone solvent.[2]
Doxylamine is used for treatment of:
Side effects of doxylamine are:
Q.1 Match the following with correct SAR of the ethanolamine ether antihistamine drugs-
i. 8-chlorotheophyllinate salt of diphenhydramine gives a drug knows as | A. Dimenhydrinate |
ii. Compounds with para-chlorophenyl groups and 2-pyridyl aryl groups are | B. Clemastine |
iii. An additional carbon atom between oxygen and nitrogen produces | C. Setastine |
iv. Alkyl amine substituent is incorporated into seven-membered hexahydroazepine ring to give | D. Carboxamine |
a. i-D, ii-A, iii-C, iv-B
b. i-D, ii-A, iii-C, iv-B
c. i-A, ii-D, iii-B, iv-C
d. i-A, ii-B, iii-D, iv-C
Q.2 Correct sequence for the True/False for correct IUPAC names of the drug can be?
a) TFFT
b) FFTT
c) FTFT
d) TTTT
Q.3 The correct physical appearance of doxylamine is?
a) Clear colorless liquid
b) Yellow oily liquid
c) White crystalline solid
d) Reddish-brown crystals
Q.4 Doxylamine inhibits?
a) H1 receptors
b) H2 receptors
c) Muscarinic receptors
d) Nicotinic receptors
Q.5 Which amongst the following is not a therapeutic use of drug Doxylamine?
a) Treatment of Bradycardia
b) Treatment of Allergic symptoms
c) Treatment of hay fever
d) Treatment of Runny nose
Q.6 Which of the following drug and their classification are correct?
I. Doxylamine: Ethanolamine ether antihistamine drug
II. Sevoflurane: Inhalational anesthetics
III. Bisoprolol: Alpha adrenergic blockers
IV. Lorazepam: Benzodiazepine sedative hypnotics
a) I, IV
b) I, II
c) II, III
d) III, IV
Q.7 Doxylamine can be converted into Doxylamine succinate by reaction with?
a) Succinic acid in Acetone solvent
b) Succinic acid in NaOH solution
c) Oxalic acid in Acetone solvent
d) Oxalic acid in NaOH solution
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1-c
2-d
3-a
4-a
5-a
6-b
7-a
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