The post PROCYCLIDINE HYDROCHLORIDE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
]]>1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol;hydrochloride.
Procyclidine is an acetylcholine antagonist. It is a muscarinic antagonist.
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 323.9 g/mol |
2 | Physical appearance | White crystalline substance |
3 | Melting point | 86°C. |
4 | Solubility | Soluble in water |
5 | Octanol/water partition coefficient | 4.2 |
6 | Presence of ring | Benzene, pyrrolidine, cyclohexane |
7 | Number of chiral centers | 1 |
i. cyclohexyl(phenyl) methanone reacts with ethyl-2-bromoacetate and (S)-1-phenylethylamine to give (S)-3-cyclohexyl-3-hydroxy-3-phenylpropanoic acid.
ii. The latter compound is reacted with B2H6 to give (S)-1-cyclohexyl-1-phenylpropane-1,3-diol.
iii. On reaction with triphenylphosphine, (S)-3-chloro-1-cyclohexyl-1-phenylpropan-1-ol ca be obtained.
iv. Ontreating with pyrrolidine, procyclidine hydrochloride is produced. [1]
Procyclidine hydrochloride is used for:
Side Effects
Side effects of procyclidine are:
Q.1 Correct statements related with the Physicochemical properties of Procyclidine hydrochloride are?
I. Molecular weight = 496 gm/mol
II. Physical appearance: present in white crystalline substance form
III. Melting point = 199.5°C
IV. Solubility: soluble in water
a) I, III
b) I, II, IV
c) II, IV
d) I
Q.2 Match the following of the drugs with their correct IUPAC names.
i. Methacholine | A. 2-(Acetyloxy)-N,N,N-trimethylpropan-1-aminium. |
ii. Homatropin | B. (RS)-(8-Methyl-8-azabicyclo[3.2.1]oct-3-yl) 3-hydroxy-2-phenylpropanoate |
iii. Procyclidine | C. (N-Methyl-8-azabicyclo[3.2.1]oct-3-yl) 2-hydroxy-2-phenylacetate |
iv. Atropin | D. 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol |
a) i-B, ii-A, iii-D, iv-C
b) i-A, ii-C, iii-D, iv-B
c) i-D, ii-C, iii-B, iv-A
d) i-A, ii-B, iii-C, iv-D
Q.3 Complete the following sentence related with the mechanism of action of Procyclidine hydrochloride.
‘Procyclidine ………….. the central cholinergic receptors and ………..the cholinergic and dopaminergic activity in the basal ganglia.’
a) blocks, balances
b) stimulates, balances
c) balances, blocks
d) balances, stimulates
Q.4 Correct sequence for True/false for the classification of the drug can be?
a) FTFT
b) TTTF
c) TFTF
d) FFTT
Q.5 Maximum potency obtained when the distance between the ring substituted carbons in procyclidine hydrochloride is?
a) 1 carbon unit
b) 4 carbon unit
c) 2 carbon unit
d) 7 carbon unit
Q.6 The correct sequence for the steps for synthesis of drug Procyclidine hydrochloride from ‘cyclohexyl(phenyl) methanone’?
I. Treatment with pyrrolidine
II. Reaction with triphenylphosphine
III. Reaction with diborane
IV. Reaction with ethyl-2-bromoacetate
a) I – II
b) IV – III – II – I
c) I – III – II – IV
d) III – IV
Q.7 Side effect of drug procyclidine hydrochloride?
a) Allergic reactions
b) Dry mouth
c) Constipation
d) All of the above
1-c
2-b
3-a
4-a
5-c
6-b
7-d
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