The post ETODOLAC Synthesis, SAR, MCQ, Structure, Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
]]>(RS)-2-(1,8-Diethyl-4,9-dihydro-3H-pyrano[3,4-b]indol-1-yl)acetic acid
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 287.35 g/mol |
2 | Physical appearance | Solid |
3 | Melting point | 146.5°C |
4 | Solubility | 16 mg/L |
5 | Octanol/water partition coefficient | 2.5 |
6 | Presence of ring | Indole, pyran |
7 | Number of chiral centers | 1 |
SAR of class Pyranocarboxylic acid can be summarized as follows:
i. To the solution of 2-ethyl phenyl hydrazine hydrochloride in DMAc-H2O; 2,3-dihydrofuran is added drop-wise and heated to get 7-ethyl tryptophol.
ii. 7-ethyltryptophol is reacted with methyl-3-oxopentanoate followed by hydrolysis to give etodolac.[2]
Etodolac is used for:
Side effects of Etodolac are:
Q.1 Which statements are correct with respect to the physicochemical properties of drug etodolac?
I. Molecular weight:287.35 gm/mol
II. Appearance: It is solid
III. Melting point: 146.5oC
a) I, II
b) II, III
c) I, II, III
d) I, III
Q.2 Match the following of the drugs with their correct IUPAC names.
i. Etodolac | A. ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylate |
ii. Pentazocine | B. (5α,6α)-7,8-didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol |
iii. Diphenoxylate | C. (RS)-2-(1,8-Diethyl-4,9-dihydro-3H-pyrano[3,4-b]indol-1-yl)acetic acid |
iv. Codeine | D. 2-dimethylallyl-5,9-dimethyl-2′-hydroxybenzomorphan |
a) i-C, ii-D, iii-A, iv-B
b) i-D, ii-B, iii-A, iv-C
c) i-C, ii-A, iii-D, iv-B
d) i-B, ii-C, iii-D, iv-A
Q.3 Mechanism of action of etodolac includes?
I. Antipyresis effects due to action on hypothalamus
II. Inhibition of COX-1 enzyme
III. Inhibition of COX-2 enzyme
IV. Reducing the level of Ach synaptic junction
a) II, IV
b) I, II, III
c) I, IV
d) II, III, IV
Q.4 Correct sequence for True/false for the classification of the drug can be?
a) TFFT
b) FTFT
c) FFTF
d) TTTT
Q.5 Most active compound of class Pyranocarboxylic acid derivative NSAIDs was found to be?
a) 7-fluoro-8-methyl derivatives
b) 8-butyl derivatives
c) 2-methyl derivatives
d) All of the above have same activitiesolac can synthesized from 7-ethyltryptophol through the steps-
I. ydrolysis
II. Reaction with methyl-3-oxopentanoate
III. Reduction
IV. Decarboxylation
a) II – III – I
b) II – IV – I
c) IV – I – II
d) II – I
Q.7 Side effect of drug Etodolac?
a) Allergic reactions
b) Shortness of breath
c) Stomach bleeding
d) All of the above
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1-c
2-a
3-b
4-a
5-a
6-d
7-d
for etodolac, a non steroidal anti- inflammatory drug. IOSR Journal of Applied Chemistry. Vol. 4 (5), 2013, pp. 3-5
The post ETODOLAC Synthesis, SAR, MCQ, Structure, Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
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