The post FLUBIPROFEN Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
]]>(RS)-2-(2-fluorobiphenyl-4-yl)propanoic acid
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 244.26 g/mol |
2 | Physical appearance | Solid |
3 | Melting point | 110.5°C |
4 | Solubility | 8 mg/ml |
5 | Octanol/water partition coefficient | 3.8 |
6 | Presence of ring | Biphenyl |
7 | Number of chiral centers | 1 |
SAR of propionic acid derivatives can be summarized as follows:
i. Coupling reaction between 2-(4-amino-3-fluorophneyl) ethyl propionate and benzene through Gomberg-bachmann reaction and taking isoamyl nitrile as diazotization reagent and silica gel as dehydrating agent to obtain 2-(2-fluoro-4-biphenyl) ethyl propionate.
ii. On hydrolysis of the last gives flubiprofen with 50% yield. [2]
Flubiprofen is used for:
Side effects of Flubiprofen are:
Q.1 Mechanism of action of Flubiprofen is due to?
a) Reversibly inhibition of COX enzyme
b) Irreversibly inhibition of COX enzyme
c) Reversibly inhibition of Anticholinestrase
d) Irreversibly inhibition of Anticholinestrase
Q.2 Therapeutic use of drug Flubiprofen is/are?
a) Reducing pain due to Rheumatoid arthritis
b) Treatment of vascular degeneration
c) As an anesthesia prior to dental surgery
d) All of the above
Q.3 Which amongst the following are the correct statements with respect to the SAR of Propionic acid NSAIDs?
I. Anti-inflammatory activity of the drug can be increased by substitution of an α-methyl group on the alkanoic acid portion of acetic acid derivatives.
II. Related side effects of the drug can be decreased by substitution of an α-methyl group on the alkanoic acid portion of acetic acid derivatives.
III. (+)-enantiomer possess greater activity than (-)-enantiomer
a) I, II, III
b) II
c) I, III
d) II, III
Q.4 Number of chiral centers present in the structure of Flubiprofen is?
a) 3
b) 5
c) 1
d) 4
Q.5 Correct sequence for the True/False for the physiochemical properties of the drug Flubiprofen?
a) TFFT
b) FTTF
c) TTFF
d) FFFF
Q.6 Correct statements for the IUPAC nomenclatures of the drugs are?
I. Flubiprofen: (RS)-2-(2-fluorobiphenyl-4-yl)propanoic acid
II. Haloperidol: 4-[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
III. 6-Mercaptopurine: 3,7-dihydropurine-6-thione
IV. Mechlorethamine: 2-Chloro-N-(2-chloroethyl)-N-methylethan-1-amine
a) I, II
b) II, III, IV
c) I, IV
d) I, II, III, IV
Q.7 Match the following drugs with their correct classifications-
i. Flubiprofen | A. Barbiturate anticonvulsant |
ii. Phenobarbital | B. NSAIDs |
iii. Pyridostigmine | C. Benzodiazepine sedative hypnotic |
iv. Lorazepam | D. Cholinestrase inhibitor |
a) i-A, ii-D, iii-B, iv-C
b) i-B, ii-A, iii-D, iv-C
c) i-B, ii-C, iii-A, iv-D
d) i-A, ii-B, iii-C, iv-D
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1-a
2-a
3-a
4-c
5-b
6-d
7-b
The post FLUBIPROFEN Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
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