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]]>1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 390.9 g/mol |
2 | Physical appearance | Solid |
3 | Melting point | 217-224oC |
4 | Solubility | 0.1g/100ml |
5 | Octanol/water partition coefficient | 5.8 |
5 | Presence of ring | Piperazine, phenyl |
6 | Number of chiral centers | Not present |
Structure activity of piperizine antihistamines can be summarized as:
Reductive deamination of 3-methylbenzaldehyde with 1-(4-chlorbenzhydryl)piperazine using hydrogen over Raney nickel produces meclizine. [1]
Meclizine is used for treatment of:
Side effects of Meclizine are:
Q.1 “1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine” is the IUPAC nomenclature of which drug?
a) Loperamide
b) Meclizine
c) Buclizine
d) Lansoprazol
Q.2 Melting point of meclizine is?
a) 520oC
b) 217-224oC
c) 120oC
d) 25oC
Q.3 Match the following with correct classifications of the drugs.
i. Meclizine | A. Analgesic |
ii. Levorphanol | B. ß-blocker |
iii. Atenolol | C. Anticonvulsant |
iv.Phensuximide | D. H1-receptor antihistamine |
a) i-A, ii-D, iii-C, iv-B
b) i-D, ii-C, iii-A, iv-B
c) i-D, ii-A, iii-B, iv-C
d) i-B, ii-D, iii-A, iv-C
Q.4 Mechanism of action of Meclizine includes?
I. Antagonistic effects on H1-receptor.
II. Decrease in the vestibular stimulation and labyrinth excitability.
III. Inhibition of Hydrogen/Potassium pump
IV. Inhibition of COX-2 enzyme
a) I, II
b) II, IV
c) I, II, III
d) III
Q.5 Correct sequence for True and False for the given statements related with the SAR of Piperazine antihistamines can be?
a) TTFT
b) TFTF
c) TTTT
d) FTTT
Q.6 Reductive deamination of 3-methylbenzaldehyde with 1-(4-chlorbenzhydryl)piperazine using hydrogen over Raney nickel produces which drug?
a) Methotrexate
b) Omeprazol
c) Meclizine
d) Carbinoxamine
Q.7 The drug Meclizine is mainly used for treatment of?
a) Nausea
b) Dizziness
c) Symptoms of vertigo
d) All of the above
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1-b
2-b
3-c
4-b
5-c
6-c
7-d
The post MECLIZINE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
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