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]]>gold(1+);3,4,5-triacetyloxy-6-(acetyloxymethyl)oxane-2-thiolate;triethylphosphanium
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 679.5 g/mol |
2 | Physical appearance | White crystalline powder |
3 | Melting point | 112-115oC |
4 | Solubility | Insoluble in water |
5 | Octanol/water partition coefficient | N/A |
6 | Presence of ring | Pyran |
7 | Number of chiral centers | 5 |
General SAR for Gold compounds can be summarized as follows:
i. Reaction of thioether with silver nitrate or any other heavy metal salt to give silver salt of sugar thiol.
ii. On reacting the last with tert-phosphine gold reagent produces auranofin.[2]
Auranofin is used for:
Side effects of Auranofin are:
Q.1 “gold(1+);3,4,5-triacetyloxy-6-(acetyloxymethyl)oxane-2-thiolate;triethylphosphanium” is the IUPAC nomenclature of which drug?
a) Gold sodium thiomalate
b) Aurothioglucose
c) Auranofin
d) Oxymetazoline
Q.2 Appearance of auranofin is?
a) White crystalline solid
b) Yellow powder
c) Black amorphous solid
d) None of the above
Q.3 Match the following with correct classifications of the drugs.
i. Auranofin | A. Non-selective adrenergic agonist |
ii. Norepinephrin | B. Cholinestrase reactivator |
iii. Pralidoxime | C. ß-blocker |
iv. Carvedilol | D. DMARDs |
a) i-A, ii-D, iii-B, iv-C
b) i-D, ii-A, iii-B, iv-C
c) i-D, ii-C, iii-A, iv-B
d) i-C, ii-D, iii-A, iv-B
Q.4 Correct statements from below which are related with the mechanism of action of Auranofin can be??
I. It inhibits thioredoxin reductase enzyme
II. It activates thioridoxin reducatse enzyme
III. It decreases the immune response
IV. It increases the immune response
a) I, III
b) I, IV
c) II, III
d) II, IV
Q.5 Correct sequence for True and False for the given statements related with the SAR of Anti-inflammatory gold compounds can be?
a) TFFT
b) FFTT
c) FTFT
d) TTTT
Q.6 Silver salt of sugar thiol can produce Auranofin by reaction with?
a) Baeyer’s reagent
b) Silver nitrate
c) Tert-phosphine gold reagent
d) Lead acetate
Q.7 The drug Auranofin is mainly used for?
a) Treatment of Parkinson disease
b) For reversing the toxicity due to cholinergic drugs
c) Reducing pain due to arthritis
d) All of the above
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1-c
2-a
3-b
4-a
5-c
6-c
7-c
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