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]]>2-Bromo-2-chloro-1,1,1-trifluoroethane
Halothane is a hydrocarbon inhalational anesthetic.
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 197.38g/mol |
2 | Physical appearance | Clear colourless highly volatile liquid |
3 | Boiling point | 50.2°C |
4 | Solubility | It is miscible with petroleum ether and other fat solvents. |
5 | Octanol/water partition coefficient | 2.3 |
6 | Presence of ring | Not present |
7 | Number of chiral centers | 1 |
The SAR for inhaled anesthetics can be summarized as follows:
i. Hydrogen fluoride is added to trichloroethylene and on simultaneous substitution of chloride atoms in presence of antimony(III) chloride at 130oC produces 2-chloro-1,1,1-trifluoroethane.
ii. The above formed compound undergoes bromination at 450oC to produce halothane. [1]
Halothane is used for:
Side effects of halothane are:
Q.1 “2-Bromo-2-chloro-1,1,1-trifluoroethane” is the IUPAC nomenclature of which drug?
a) Chlorpromazine
b) Halothane
c) Dutasteride
d) Fulvestrant
Q.2 Correct melting point of the drug Halothane is?
a) 155°C
b) 50.2°C
c) 115.6°C
d) 15.7°C
Q.3 Match the following with correct classifications of the drugs.
i. Methsuximide | A. Inhalational anesthetics |
ii. Diazepam | B. ß-blockers |
iii. Halothane | C. Sedative hypnotic |
iv. Betazolol | D. Anticonvulsant drug |
a) i-A, ii-C, iii-D, iv-B
b) i-C, ii-A, iii-B, iv-D
c) i-D, ii-C, iii-A, iv-B
d) i-A, ii-D, iii-C, iv-B
Q.4 Mechanism of action of drug Halothane includes?
I. Binding with acetylcholine receptors
II. Binding with potassium channels
III. Promoting the prostaglandin production
IV. Binding with NMDA
a) I, IV
b) II, IV
c) I, III, IV
d) I, II
Q.5 Correct sequence for True and False for the given statements related with the SAR of Inhaled anesthetics drugs?
a) FFTT
b) TFTF
c) TFFT
d) FTTT
Q.6 Which drug is formed on bromination of 2-chloro-1,1,1-trifluoroethane?
a) Halothane
b) Benzazepam
c) Phensuximide
d) Cetrizine
Q.7 The drug Halothane is mainly used for?
a) As an anesthetic
b) Treatment of pain
c) As an anti-inflammatory agent
d) All of the above
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1-b
2-b
3-c
4-b
5-d
6-a
7-a
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