The post HOMATROPIN (HYOSCINE) Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
]]>(N-Methyl-8-azabicyclo[3.2.1]oct-3-yl) 2-hydroxy-2-phenylacetate.
Homatropin is a acetylcholine antagonist-muscarinic antagonist.
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 275.34 g/mol |
2 | Physical appearance | White to fine-white crystalline powder |
3 | Melting point | 99.5°C. |
4 | Solubility | Water solubility is 5.57 mg/ml |
5 | Presence of ring | Benzene and aza bicyclooctane rings present |
6 | Number of chiral centers | 4 |
i. Tropin and 2-phenyl-2-(vinyloxy)acetyl chloride undergoes esterification reaction to give 8-methyl-8aza-bicyclo[.2.1]octan-3-yl 2-phenyl-2-(vinyloxy)acetate.
ii. The latter compound undergoes acidic hydrolysis to give Homatropin.
Homatropin is used for:
Side Effects
Side effects of homatropin are:
Q.1 Correct statements related with the Physicochemical properties of Homacycline are?
I. Molecular weight = 496 gm/mol
II. Physical appearance : present in viscous liquid form
III. Melting point = 99.5°C
IV. Solubility: very soluble in water
a) I, III
b) I, II, IV
c) II, IV
d) I
Q.2 Match the following of the drugs with their correct IUPAC names.
i. Methacholine | A. 2-(Acetyloxy)-N,N,N-trimethylpropan-1-aminium. |
ii. Homatropin | B. (RS)-(8-Methyl-8-azabicyclo[3.2.1]oct-3-yl) 3-hydroxy-2-phenylpropanoate |
iii. Procyclidine | C. (N-Methyl-8-azabicyclo[3.2.1]oct-3-yl) 2-hydroxy-2-phenylacetate |
iv. Atropin | D. 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol |
a) i-B, ii-A, iii-D, iv-C
b) i-A, ii-C, iii-D, iv-B
c) i-D, ii-C, iii-B, iv-A
d) i-A, ii-B, iii-C, iv-D
Q.3 Correct steps for the mechanism of action of the drug Homatropin?
I. Antagonizing muscarinic receptors
II. Agonizing muscarinic receptors
III. Blocks the responses from iris sphincture muscle and cause pupil to become unresponsive to light upon dilation or mydriasis.
a) I – III
b) II – III
c) III – I
d) III – II
Q.4 Correct sequence for True/false for the classification of the drug can be?
a) FTFT
b) TTTF
c) TFTF
d) FFTT
Q.5 Maximum potency obtained when the distance between the ring substituted carbons is?
a) 1 carbon unit
b) 4 carbon unit
c) 2 carbon unit
d) 7 carbon unit
Q.6 The correct sequence for the steps for synthesis of drug Homatropin from 2-phenyl-2-(vinyloxy)acetyl chloride?
I. Reaction with trimethylamine
II. Reaction with acetic anhydride
III. Esterification with tropin
IV. Hydrolysis
a) I – II
b) I – III – II
c) I – III – II – IV
d) III – IV
Q.7 Side effect of drug Homatropin?
a) Burning in eye
b) Redness of eye
c) Blurred vision
d) All of the above
1-a
2-b
3-a
4-a
5-c
6-d
7-d
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