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]]>4-[(4-methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide.
Imatinib falls under the category of antibiotic Antineoplastic cytotoxic drug. [1]
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 493.6 g/mol |
2 | Appearance | Present in solid form |
3 | Melting point | 226°C |
4 | Solubility | Very soluble in water |
5 | Octanol/water partition coefficient | 3 |
6 | Presence of ring | Imatinib consists of a pyrimidine ring, aminopyrimidine ring, methylbenzene ring, benzamide ring and N-methlpiperazine ring. |
i. It inhibits the Bcr-Abl tyrosine kinase.
ii. This inhibits the proliferation and thus, induction of apoptosis in cell.2]
Imatinib can be synthesized by the reaction of 4-methyl-N-3-(4-pyridine-3-yl-pyrimidine-2-yl)-1,2-benzenediamine with 4-(4-methyl-piperazine-1-methyl)-benzoic ester in the presence of base in a non-protonic organic solvent. [3]
Imatinib is given for the treatment of:
Q.1 The term ‘Gleevek’ is associated with which drug?
a) Triptorelin
b) Imatinib
c) 5-FU
d) 6-TG
Q.2 Introduction of methyl group in an ortho position to the amino group can ………. the selectivity of Bcr-Abl.
a) Increase
b) Decrease
c) Either increase or decrease
d) Do not change selectivity in either ways
Q.3 Which of the following are the correct side effects of the drug Imatinib?
I. High blood counts
II. Infertility
III. Shortness of breath
IV. Indigestion
a) I, II & IV
b) I, II, III & IV
c) II, III & IV
d) I, III & IV
Q.4 The starting chemicals required for the synthesis of drug Imatinib are?
a) 4-methyl-N-3-(3-yl-pyrimidine-2-yl)-1,2-benzenediamine and 4-(4-methyl-piperazine-1-methyl)-benzoic ester
b) 4-methyl-N-3-(4-pyridine-3-yl-)-1,2-benzenediamine with 4-(4-methyl-piperazine-1-methyl)-benzoic ester
c) 4-methyl-N-3-(4-pyridine-3-yl-pyrimidine-2-yl)-1,2-benzenediamine with 4-(4-methyl-piperazine-1-methyl)-butanoic ester
d) 4-methyl-N-3-(4-pyridine-3-yl-pyrimidine-2-yl)-1,2-benzenediamine with 4-(4-methyl-piperazine-1-methyl)-benzoic ester
Q.5 Which pairs of drug and its classification are true?
I. | Topotecan | Captothecin analogues |
II. | Vincrisine | Progestins |
III. | Imatinib | Antibiotic |
IV. | Carmustine | Glucocorticoids |
a) I
b) II & III
c) I & III
d) I & IV
Q.6 Correct physical form in which the drug Imatinib is found at normal temperature and pressure?
a) Solid form
b) Solid crystalline form
c) Liquid form
d) Gaseous form
Q.7 Which of the following rings is NOT present in the structure of Imatinib?
a) Pyrimidine ring
b) Pteridine ring
c) Benzamide ring
d) Aminopyrimidine ring
1-b
2-a
3-c
4-d
5-a
6-a
7-b
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