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]]>Ipratropium is an acetylcholine antagonist. It is a muscarinic antagonist.
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 412.4 g/mol |
2 | Physical appearance | Almost white crystalline powder |
3 | Melting point | 231°C. |
4 | Solubility | Freely soluble in water |
5 | Presence of ring | Present |
6 | Number of chiral centers | 5 |
i. The drug inhibits the parasympathetic nervous system in the airways.
ii. Ipratropium stops the activity of acetylcholine in the smooh muscles preventing the contraction and relaxed airways.
iii. This leads to bronchodilation and a fewer secretions. [1]
i. Tropic acid and tropine reacts to give atropine.
ii. Treating atropine with isopropyl bromide gives ipratropium bromide. [2]
Ipratropium bromide is used for controlling and prevention of symptoms of:
Side effects of Ipratropium bromide are:
Q.1 What can be the correct IUPAC nomenclature of Ipratropium bromide?
a) (RS)-1-(1-methylethylamino)-3-(1-naphthyloxy)propan-2-ol.
b) [8-methyl-8-(1-methylethyl)- 8-azoniabicyclo[3.2.1] oct-3-yl] 3-hydroxy-2-phenyl-propanoate
c) (RS)-(8-Methyl-8-azabicyclo[3.2.1]oct-3-yl) 3-hydroxy-2-phenylpropanoate
d) 2-[(Aminocarbonyl)oxy]-N,N,N-trimethylethanaminium chloride.
Q.2 Which amongst the following statements is/are incorrect related to the SAR of Ipratropium bromide?
I. X can also be either oxygen or absent completely.
II. The N substituent can be quarternary ammonium salt or tertiary amine or both with different alkyl groups.
III. Minimum potency obtained when the distance between the ring substituted carbons is 2 carbon units.
a) III
b) I
c) II, I
d) II, III
Q.3 The interaction of Atropine and isopropylbromide produces?
a) Ipratropium bromide
b) Carbachol
c) Procyclidine
d) Doxacurium
Q.4 Side effects of drug Ipratropium bromide is/are?
a) Allergic reactions
b) Constipation
c) Dryness in mouth
d) All of the above
Q.5 Match the following drugs with correct number of chiral carbons they are having.
i. Propranolol | A. 1 |
ii. Carbachol | B. 4 |
iii. Ipratropium bromide | C. 0 |
iv. Atropine | D. 5 |
a) i-A, ii-C, iii-B, iv-D
b) i-D, ii-,B iii-A, iv-C
c) i-B, ii-D, iii-A, iv-C
d) i-A, ii-C, iii-D, iv-B
Q.6 An example of drug from class Acetylcholie Antagonist (muscarinic antagonist) is?
a) Donepezil
b) Carbachol
c) Ipratropium
d) Paraoxin
Q.7 The type of ring system found in Ipratropium?
a) Benzene
b) Napthalene
c) Imidazole
d) None of the above
1-b
2-a
3-a
4-d
5-d
6-c
7-a
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