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]]>(RS)-2-(3-benzoylphenyl)propanoic acid
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 254.28 g/mol |
2 | Physical appearance | Solid |
3 | Melting point | 94°C |
4 | Solubility | 51 mg/ml |
5 | Octanol/water partition coefficient | 3.12 |
6 | Presence of ring | Phenyl |
7 | Number of chiral centers | 1 |
SAR of ketoprofen can be summarized as follows:
i. 3-methylbenzophenone undergoes bromination to form 3-bromo-methylbenzophenone.
ii. Latter compound is reduced with help of sodium cyanide to give 3-cyanomethylbenzophenone.
iii. The last is reacted with diethyl ester of carbonic acid in presence of sodium ethoxide to give cyanoacetic ester derivative.
iv. On alkylation of the above formed compound by methyl iodide followed by acidic hydrolysis gives ketoprofen. [2]
Ketoprofen is used for:
Side effects of Ketoprofen are:
Q.1 Match the following with correct SAR of the class Oxicams NSAIDs-
i. On placing the phenoxy group in the ortho or para position of the arylpropionic acid | A. increases the activity |
ii. Replacing carbonyl group between two aromatic rigs with oxygen bridge produces another marketed analogue known as | B. decreases the activity |
C. Ibuprofen | |
D. Fenoprofen |
a) i-A, ii-C
b) i-A, ii-D
c) i-B, ii-C
d) i-B, ii-D
Q.2 Correct sequence for the True/False for correct IUPAC names of the drug can be?
a) TFTF
b) FFFF
c) TTTT
d) TFFT
Q.3 Molecular weight of drug Ketoprofen is?
a) 351.8 gm/mol
b) 254.28 gm/mol
c) 426.21 gm/mol
d) 62.1 gm/mol
Q.4 Ketoprofen mechanism of action includes?
a) It exerts effect only on COX-2 and not on COX-1
b) It effects lead to vasoconstriction
c) It exerts effect on COX-1 and on COX-2
d) It does not produce any effect on COX
Q.5 Which amongst the following is a therapeutic use of drug Ketoprofen?
a) Treatment of bronchospasm
b) Reducing pain due to arthritis
c) Controlling vomiting
d) All of the above
Q.6 Which of the following drug and their classification are correct?
I. Ketoprofen: NSAID
II. Ketoprofen: Propionic acid derivative
III. Methoxyflurane: Inhalational anesthetics
IV. Alprazolem: ß-adrenergic blocker
a) III, IV
b) I, II, III
c) I, II, III, IV
d) II
Q.7 Number of chiral carbons resent in the structure of ketoprofen is?
a) 5
b) 2
c) 1
d) 0
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1-d
2-b
3-b
4-c
5-b
6-b
7-c
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