The post MECLOFENAMIC ACID Synthesis, SAR, MCQ, Structure, Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
]]>2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 296.1 g/mol |
2 | Physical appearance | Solid |
3 | Melting point | 257°C |
4 | Solubility | 30 mg/L |
5 | Octanol/water partition coefficient | 5 |
6 | Presence of ring | Phenyl |
7 | Number of chiral centers | Not present |
General SAR for anthranylic acid derivatives can be summarized as follows:
Reaction of potassium salt of 2-bromobenzoic acid with 2,6-dichloro-3-methylaniline in presence of copper (II) bromide in a mixture of N-ethylmorpholine and diglyme produces meclofenamic acid. [2]
Meclofenamic acid is used for:
Side effects of meclofenamic acid are:
Q.1 Which statements are correct with respect to the physicochemical properties of drug Meclofenamic acid?
I. Molecular weight:296.1 gm/mol
II. Appearance: Transparent liquid
III. Melting point: 257oC
a) I, II
b) II
c) I, II, III
d) I, III
Q.2 Match the following of the drugs with their correct IUPAC names.
i. Meclofenamic acid | A. 4-hydroxy-2-methyl-N-(5-methyl-1,2-oxazol-3-yl)-1,1-dioxo-1λ6,2-benzothiazine-3-carboxamide |
ii. Ibuprofen | B. [2-(2,6-Dichloroanilino)phenyl]acetic acid |
iii. Isoxicam | C. 2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid |
iv. Paracetamol | D. (RS)-2-(4-(2-Methylpropyl)phenyl)propanoic acid
|
a) i-C, ii-D, iii-A, iv-B
b) i-D, ii-B, iii-A, iv-C
c) i-C, ii-A, iii-D, iv-B
d) i-B, ii-C, iii-D, iv-A
Q.3 Mechanism of action of Meclofenamic acid includes?
I. Inhibition of the synthesis of prostaglandins
II. Inhibition of acetylcholinestrases enzymes
III. Drug competes for binding site at prostaglandin receptor
IV. Decrease in level of ACh
a) II, IV
b) I, II, III, IV
c) I, III
d) II, III, IV
Q.4 Correct sequence for True/false for the classification of the drug can be?
a) TFFT
b) FTFT
c) TTTT
d) TTFF
Q.5 An incorrect statement related with the SAR of Anthranylic acid derivatives is?
a) Activity decreases when substitution on anthranilic acid ring.
b) Activities due to substitution on the N-aryl ring follows the general order m > o > p.
c) For disubstitution products, activity was found to be minimum when o and m positions are substituted near to each other on the N-aryl ring.
d) Substitutions on the N-aryl ring with such groups which leads the ring to be noncoplanar with the anthranilic acid ring increases the binding of the drug and hence, increases the activity
Q.6 Which drug is synthesized on reaction of 2-bromobenzoic acid with 2,6-dichloro-3-methylaniline in presence of copper(II) bromide?
a) Flufenamic acid
b) Meclofenamic acid
c) Tolazoline
d) Physostigmine
Q.7 Side effect of drug Meclofenamic acid?
a) Difficulty in urination
b) Jaundice
c) Weight gain
d) All of the above
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1-d
2-a
3-c
4-b
5-c
6-b
7-d
The post MECLOFENAMIC ACID Synthesis, SAR, MCQ, Structure, Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
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