The post MEFENAMIC ACID Synthesis, SAR, MCQ, Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
]]>2-(2,3-dimethylphenyl)aminobenzoic acid
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 241.28 g/mol |
2 | Physical appearance | White to off-white crystalline powder |
3 | Melting point | 230.5°C |
4 | Solubility | Soluble in solution of alkali hydroxides; sparingly soluble in ether; slightly soluble in ethanol |
5 | Octanol/water partition coefficient | 4.2. |
6 | Presence of ring | Phenyl |
7 | Number of chiral centers | Not present |
General SAR for anthranylic acid derivatives can be summarized as follows:
Potassium salt of 2-bromobenzoic acid is reacted with ,3-dimethylaniline in the presence of copper(II) acetate to give mefenamic acid. [2]
Mefenamic acid is used for:
Side effects of mefenamic acid are:
Q.1 What can be the correct IUPAC nomenclature of Mefenamic acid?
a) 2-(2,3-dimethylphenyl)aminobenzamide
b) 2-(2,3-dimethylphenyl)aminobenzoic acid
c) 4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-ylthieno[2,3-e]thiazine-3-carboxamide
d) 4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-ylthieno[2,3-e]thiazine-3-Carboxylic acid
Q.2 Which amongst the following statements is/are incorrect related to the SAR of Anthranylic acid derivatives?
I. Activity decreases when substitution on anthranilic acid ring.
II. Activities due to substitution on the N-aryl ring follows the general order m > o > p.
III. For disubstitution products, activity was found to be minimum when o and m positions are substituted near to each other on the N-aryl ring.
IV. Substitutions on the N-aryl ring with such groups which leads the ring to be noncoplanar with the anthranilic acid ring increases the binding of the drug and hence, increases the activity
a) I
b) III
c) I, II
d) IV
Q.3 Mefenemic acid can be synthesized by the reaction of 2,3-dimethylbenzamine in presence of copper(II)acetate with?
a) Potassium 2-bromo-benzoate
b) Saccharine
c) Mulch’s reagent
d) All of the above
Q.4 Side effects of drug mefenamic acid is/are?
a) Skin rash
b) Abdominal pain
c) Easy bleeding
d) All of the above
Q.5 Match the following drugs with the correct number of the chiral carbons they have in their structure:
i. Mefenamic acid | A. 3 |
ii. Etodolac | B. 1 |
iii. Naloxone | C. 2 |
iv. Dextropropoxyphene | D. 0 |
a) i-A, ii-C, iii-D, iv-B
b) i-D, ii-A, iii-C, iv-B
c) i-D, ii-B, iii-A, iv-C
d) i-B, ii-D, iii-A, iv-C
Q.6 An example of drug from class NSAIDs?
a) Methotrexate
b) Glycopyrrolate
c) Mefenamic acid
d) Salbutamol
Q.7 The type of ring system found in Mefenamic acid?
I. Phenyl
II. Pyridine
III. Anthracene
IV. Thiophene
a) I, III
b)II, III, IV
c) I
d) II, IV
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1-b
2-b
3-a
4-d
5-c
6-c
7-c
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