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]]>2-(Acetyloxy)-N,N,N-trimethylpropan-1-aminium.
Methacholine is a cholinergic agonist falls in the class of choline esters.
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 160.23 g/mol |
2 | Physical appearance | Present in solid form |
3 | Melting point | 171-173°C |
4 | Solubility | Water solubility is 0.0947mg/ml |
5 | Presence of ring | Not present |
6 | Number of chiral centers | 1 |
i. Addition of trimethylamine to propylene chlorohydrins gives (2-hydroxypropyl)trimethylammonium ion.
ii. The latter compound on reaction with acetic anhydride forms methacholine.
Methacholine is used for test of:
Side effects of methacholine are:
Q.1 Correct statements related with the Physicochemical properties of Methacholine are?
I. Molecular weight = 160.23 gm/mol
II. Physical appearance : present in viscous liquid form
III. Melting point = 35°C
IV. Solubility: very soluble in water
a) I, III
b) I, II, IV
c) II, IV
d) I
Q.2 Match the following of the drugs with their correct IUPAC names.
i. Methacholine | A. 2-(Acetyloxy)-N,N,N-trimethylpropan-1-aminium. |
ii. Homatropin | B. (RS)-(8-Methyl-8-azabicyclo[3.2.1]oct-3-yl) 3-hydroxy-2-phenylpropanoate |
iii. Procyclidine | C. (N-Methyl-8-azabicyclo[3.2.1]oct-3-yl) 2-hydroxy-2-phenylacetate |
iv. Atropin | D. 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol |
a) i-B, ii-A, iii-D, iv-C
b) i-A, ii-C, iii-D, iv-B
c) i-D, ii-C, iii-B, iv-A
d) i-A, ii-B, iii-C, iv-D
Q.3 Correct steps for the mechanism of action of the drug Methacholine?
I. Antagonizing muscarinic receptors
II. Agonizing muscarinic receptors
III. Induction of bronchoconstriction
a) I – III
b) II – III
c) III – I
d) III – II
Q.4 Correct sequence for True/false for the classification of the drug can be?
a) FTFT
b) TTTF
c) TFTF
d) FFTT
Q.5 Number of atoms requires between nitrogen and terminal hydrogen to have maximum activity for Methacholine is?
a) 1
b) 4
c) 5
d) 7
Q.6 The correct sequence for the steps for synthesis of drug Methacholine from Propyline chlorohydrine?
I. Reaction with trimethylamine
II. Reaction with acetic anhydride
III. Reduction
IV. Oxidation
a) I – II
b) I – III – II
c) I – III – II – IV
d) III – II – IV
Q.7 Side effect of drug Methacholine?
a) Dizziness
b) Sore throat
c) Lightheadedness
d) All of the above
1-d
2-b
3-b
4-a
5-c
6-a
7-d
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