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]]>(RS)-6-(dimethylamino)-4,4-diphenylheptan-3-one
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 309.4 g/mol |
2 | Physical appearance | Solid |
3 | Melting point | 235°C |
4 | Solubility | Very soluble in ethanol. |
5 | Octanol/water partition coefficient | 3.93 |
6 | Presence of ring | Phenyl |
7 | Number of chiral centers | 1 |
SAR for Opiates can be summarized as follows:
i. Alkylation of 1-dimethylamino-2-propylchloride in presence of sodium amide to give 4-dimethylamino-2,2-dephenylvaleronitrile.
ii. The last compound is reacted with ethylmagnesiumbromide followed by hydrolysis.
iii. (-)-methadone is separated from racemic mixture by using (+)-tartaric acid. [1]
Methadone is used for:
Side effects Methadone are:
Q.1 Match the following with correct SAR of the Methadone.
i. Replacement of alcoholic hydroxyl with ketone group | A. Activity increases |
ii. On replacement of the methyl group from tertiary nitrogen by hydrogen atom | B. Activity decreases |
C. Activity increases | |
D. Activity decreases |
a) i-A, ii-C
b) i-A, ii-D
c) i-B, ii-C
d) i-B, ii-D
Q.2 Correct sequence for the True/False for correct IUPAC names of the drug can be?
a) TFFF
b) FTFT
c) TTTT
d) FTTF
Q.3 Correct statement related with the solubility of the drug Methadone from the following is?
a) Practically insoluble in ethanol
b) Slightly soluble in ethanol
c) Soluble in ethanol
d) Very soluble in ethanol
Q.4 Primary mechanism of action of methadone is due to?
a) Agonist activity at mu-opioid receptor
b) Agonist activity at sigma-opioid receptor
c) Antagonist activity at mu-opioid receptor
d) Antagonist activity at sigma-opioid receptor
Q.5 Which amongst the following is a therapeutic use of drug Methadone?
a) As an antidiarrheal agent
b) Relief from moderate to severe pain
c) Treatment of addiction to opioids such as heroin
d) Treatment of seizures
Q.6 Which of the following drug and their classification are correct?
I. Methadone: opioid analgesics
II. Haloperidol: buterophenone antipsychotic drug
III. Oxazepam: benzodiazepine sedative hypnotic
IV. Bitolterol: ß2-adrenergic agonist
a) I
b) II, IV
c) II, III
d) I, II, III, IV
Q.7 (-)-Methadone can be separated from the racemate by using?
a) (+)-tartaric acid
b) (-)-tartaric acid
c) Hydroxylamine
d) Sulfuric acid
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1-d
2-b
3-d
4-a
5-c
6-d
7-a
The post METHADONE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
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