The post METHYSERGIDE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
]]>(6aR,9R)-N-[(2S)-1-Hydroxybutan-2-yl]-4,7-dimethyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide.
Methysergide is an ergot alkaloid. It is a serotonin antagonist.
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 353.5 g/mol |
2 | Physical appearance | Present in crystal solid form. |
3 | Melting point | 195°C |
4 | Solubility | Water solubility is 129 mg/L |
5 | Octanol/water partition coefficient | 1.55 |
6 | Presence of ring | Ergoline ring |
7 | Number of chiral centers | 2 |
Methyl group and butanolamide group is added to the lysergic acid to give methysergide. [2]
Methysergide is used for:
Side Effects
Side effects of methysergide are:
Q.1 “(6aR,9R)-N-[(2S)-1-Hydroxybutan-2-yl]-4,7-dimethyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide” is the IUPAC nomenclature of which drug?
a) Methysergide
b) Propanolol
c) Phenoxybenzamine
d) Tamsulosin
Q.2 Melting point of Methysergide is?
a) 124°C
b) 195°C
c) 221°C
d) 143°C
Q.3 Match the following with correct classifications of the drugs.
i. Bisoprolol | A. Ergot alkaloid |
ii. Methysergide | B. ß2-adrenergic agonist |
iii. Isoproterenol | C. ß1-adrenergic antagonist |
iv. Dobutamine | D. ß1-adrenergic agonist |
a) i-B, ii-C, iii-A, iv-D
b) i-D, ii-A, iii-C, iv-B
c) i-C, ii-A, iii-D, iv-B
d) i-C, ii-A, iii-B, iv-D
Q.4 Correct steps for the mechanism of action of the drug methysergide?
I. Vasoconstriction
II. Stimulation of smooth muscles
III. Stimulation of CNS
a) III – II – I
b) I – III – II
c) II – I – III
d) II – III – I
Q.5 Correct sequence for True and False for the given statements related with the SAR of drug methysergide?
a) TT
b) FT
c)TF
d)FF
Q.6 When methyl group and butanolamide groups are added to the lysergic acid, it produces?
a) Methamphetamine
b) Alfuzosin
c) Tetrahydrozoline
d) Oxymetazoline
Q.7 The drug Methysergide is mainly used for?
a) Hypotension
b) Hypertension
c) Migraine headache
d) None of these
1-a
2-b
3-d
4-a
5-a
6-c
7-c
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