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]]>1,4-dihydroxy-5,8-bis[2-(2-hydroxyethylamino)ethylamino]-anthracene-9,10-dione.
Mitoxantron falls under the category of antibiotic Antineoplastic cytotoxic drug. [1]
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 444.5g/mol |
2 | Appearance | Present in liquid state.
Can be obtained as blue-black solid form from water ethanol. |
3 | Melting point | 203-205 °C |
4 | Solubility | Slightly soluble in methyl alcohol, sparingly soluble in water. |
5 | Octanol water partition coefficient | -3.1 |
6 | Presence of ring | Dihydroxyanthracene ring |
I. Drug intercalates with DNA by forming hydrogen bonds with the DNA. It then causes cross-linkages in the DNA and thus, causes strand breaks.
II. It interferes with topoisomerase II, which results in prevention of the repairing and recoiling of the damaged DNA strands.[2]
i. 1,8-dihydroxyanthracene-9,10-dione undergoes nitration and then treated with sodium sulfide to give 1,8-dihydroxyanthracene-9,10-dione.
ii. The above compound formed is treated with 2-(2-aminoethylamino)ethanol followed by oxidation to give mitoxantron.
Mitoxantrone is used for the treatment of:
Q.1 Which term is NOT associated with the drug Mitoxantron?
a) Novantron
b) Blenoxan
c) 1,4-dihydroxy-5,8-bis[2-(2-hydroxyethylamino)ethylamino]-anthracene-9,10-dione.
d) Mitozantron
Q.2 Match the following with respect to the physical forms of drugs
i. Mitoxantron | A. Blue-Black solid form |
ii. Daunorubicin | B. Thin red needle form |
iii. Dacarbazine | C. Pale yellow crystalline powder form |
iv. Mettronidazole | D. Ivory microcrystalline solid |
a) i-A, ii-D, iii-C, iv-B
b) i-D, ii-A, iii-B, iv-C
c) i-A, ii-D, iii-B, iv-C
d) i-A, ii-B, iii-D, iv-C
Q.3 The drug Mitoxantron shows its action through
a) Topoisomerase II inhibition
b) Cross-linkgae formation between DNA strands
c) Inhibiting the purine formation
d) Both a) and b)
Q.4 The correct order for the synthesis of the drug Mitoxantrone is
I. Treatment with sodium sulfide
II. 1,8-dihydroxyanthracene-9,10-dione undergoes nitration
III. Oxidation
IV. Reaction with 2-(2-aminoethylamino)ethanol
a) II – III – IV – I
b) I – II – IV – III
c) II – I – IV – III
d) II – IV – III – I
Q.5 Predict the incorrect statements from the following with respect to the classification of the drug.
I. Prednisolone belongs to glucocorticoids.
II. Fulvestrant is selective estrogen reseptor modulator.
III. Fosfestrol is an antibiotic cytotoxic drug.
IV. Mitoxantron is an antibiotic cytotoxic drug.
a) II & III only
b) All of the statements are incorrect.
c) I, II & III only
d) II, III & IV only
Q.6 The correct sequence of True and False for the given statements with respect to the side effects of drug Mitoxantron is?
I. Low blood counts is common side effect of drug.
II. Arrhythmia is not a side effect of the drug.
III. Hair loss may occur in the patient taking the drug.
IV. Decrease in blood tests measuring liver functions.
a) FTFT
b) TTFF
c) TFTF
d) FFTT
Q.7 Which amongst the following drugs is having highest number of ring system in its structure-
a) Mitoxantron
b) Daunorubicin
c) Dacarbazine
d) Metronidazole
1-b
2-d
3-d
4-c
5-a
6-c
7-b
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