The post Hepatitis-B : Mode of Transmission, HBV, Pathogenesis, Treatment And MCQs for NEET, GPAT, appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
]]>1.] Hepatitis – B virus [HBV] the cause of ”serum hepatitis” is the most versatile of the hepatotropic viruses.
2.] It has an longer incubation period of about 30 – 180 days and is basically transmitted such as in recipient of blood and blood products.
3.] HBV can produce severe form of illness that includes :-
4.] HBV plays role in the development of hepatocellular carcinoma (most common primary malignant tumor of the liver).
MODE OF TRANSMISSION :-
HEPATITIS – B VIRUS [HBV] :-
1.] HBV shows three forms of viral particles of 2 sizes :-
2.] Small particles are numerous and exist in two forms – as 22 nm sphere, and as tubules 22 nm in diameter and 100 nm long.
3.] Large particles, 42 nm in diameter, are double – shelled spherical particles, also called dane particles.
4.] The genomic structure of HBV is quite compact and complex. The HBV DNA consist of 4 overlapping genes which encode for multiply proteins :-
Expression of HBxAg and its antibodies associated with enhanced HBV DNA replication has been implicated in a hepatocellular carcinoma in patients of chronic hepatitis.
PATHOGENESIS :-
There are certain evidence which links immune pathogenesis with the hepatocellular damage :-
TREATMENT :-
A.] Oral Antiviral drugs for Hepatitis – B :
Tenofovir disoproxil (Viread)
Tenofovir alafenamide (Vemlidy)
Entecavir (Baraclude)
Telbivudine (Tyzeka or Sebivo)
Adefovir Dipivoxil (Hepsera)
Lamivudine (Epivir-HBV, Zeffix, or Heptodin)
B.] Immune modulators (Interferon) for Hepatitis – B :
Pegylated Interferon (Pegasys)
Interferon Alpha (Intron A)
MULTIPLE CHOICE QUESTIONS :-
1.] Which of the following hepatitis virus is not RNA virus ?
a. Hepatitis – A virus
b. Hepatitis – B virus
c. Hepatitis – E virus
d. Hepatitis – G virus
2.] Which of the following nucleic acid is present in hepatitis – B virus ?
a. dsDNA
b. ssRNA
c. ssDNA
d. dsRNA
3.] The most serious infection is ?
a. super infection of an HBsAg carrier by HDV
b. infection with HBV and HDV
c. coinfection of HBV and HDV
d. None of the above
4.] Which of the following specimen contains hepatitis B virus in an infected person ?
a. Blood
b. Semen
c. Saliva
d. All of the above
5.] Which of the following antigenic type of hepatitis B virus is present in the envelope ?
a. HbsAg
b. HBcAg
c. HBeAg
d. HBxAg
6.] The development of hepatocellular carcinoma is associated with ?
a. ground squirrel hepatitis virus
b. hepatitis B virus
c. woodchuck hepatitis virus
d. all of the above
7.] Which of the following antigenic type of hepatitis B virus is prevalent in India ?
a. Adw
b. Adr
c. Ayw
d. Ayr
8.] Which of the following virus can be transmitted by parental route ?
a. HBV
b. HCV
c. HDV
d. All of the above
9.] Incubation period of HBV virus ?
a. 30 – 180 days
b. 2 days
c. 1 week
d. 10 days
10.] The tubule of small viral particle has a diameter of about ?
a. 23 nm
b. 30 nm
c. 22 micro meter
d. 22 nm
SOLUTIONS :-
1.] (b) hepatitis – B virus
2.] (a) dsDNA
3.] (a) super infection of an HBsAg carrier by HDV
4.] (d)
5.] (a) HbsAg
6.] (d)
7.] (c) Ayw
8.] (d)
9.] (a) 30 – 180 days
10.] (d) 22 nm
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REFERENCES :-
1.] Textbook Of Pathology By Harsh Mohan; 7th edition; Page no. 591 – 592.
2.] Robbin’s Basic Pathology; 5th edition; Page no. 844 – 846.
The post Hepatitis-B : Mode of Transmission, HBV, Pathogenesis, Treatment And MCQs for NEET, GPAT, appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
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