The post NIFLUMIC ACID Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
]]>2-{[3-(trifluoromethyl)phenyl]amino}nicotinic acid
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 282.22 g/mol |
2 | Physical appearance | Solid |
3 | Melting point | 203°C |
4 | Solubility | 19 mg/L |
5 | Octanol/water partition coefficient | 4.43 |
6 | Presence of ring | Pyridine, phenyl |
7 | Number of chiral centers | Not present |
Niflumic acid acts as an anti-inflammatory drug and reduces pain through:
General SAR for anthranylic acid derivatives can be summarized as follows:
Reaction of 2-aminonicotinic acid with 1-bromo-3-trifluoromethylbenzene produces Niflumic acid. [2]
Niflumic acid is used for:
Side effects of Niflumic acid are:
Q.1 Mechanism of action of Niflumic acid is due to?
a) Inhibition of COX-1
b) Inhibition of COX-2
c) Inhibition of muscarinic receptors
d) Inhibition of nicotinic receptors
Q.2 Therapeutic use of drug Niflumic acid is/are?
a) Treatment of Pain due to rheumatoid arthritis
b) Treatment of Anemia
c) Treatment of ulceration
d) All of the above
Q.3 Which amongst the following are the correct statements with respect to the SAR of Anthranylic acid derivatives?
I. For disubstitution products, activity was found to be maximum when o and m positions are substituted near to each other on the N-aryl ring.
II. Substitutions on the N-aryl ring with such groups which leads the ring to be noncoplanar with the anthranilic acid ring increases the binding of the drug and hence, increases the activity (meclofenamic acid being more active than flufenamic acid).
III. NH-moiety of the anthranilic ring is important for the activity of the drug, and replacement of NH- moiety with O, CH3, S, SO2, N-CH3 or N-COCH3 groups decreases the activity of drug.
a) I, II, III
b) I, II
c) I, III
d) II, III
Q.4 Number of chiral centers present in the structure of Niflumic acid is?
a) 0
b) 3
c) 1
d) 2
Q.5 Correct sequence for the True/False for the physiochemical properties of the drug Niflumic acid?
a) TFFT
b) TTTT
c) TTFF
d) FFFF
Q.6 Correct statements for the IUPAC nomenclatures of the drugs are?
I. Niflumic acid: 2-{[3-(trifluoromethyl)phenyl]amino}nicotinic acid
II. Methadone: (RS)-6-(dimethylamino)-4,4-diphenylheptan-3-one
III. Anilridine: Ethyl 1-[2-(4-aminophenyl)ethyl]-4-phenylpiperidine-4-carboxylate
IV. Desflurane: 2-(difluoromethoxy)-1,1,1,2-tetrafluoroethane
a) I, II
b) I, II, III, IV
c) I, IV
d) I, II, III, IV
Q.7 Match the following drugs with their correct classifications-
i. Desflurane | A. NSAID |
ii. Codeine | B. Inhalational anesthetics |
iii. Niflumic acid | C. Opiate analgesics |
iv. Oxybutynin | D. Acetycholine antagonist |
a) i-A, ii-D, iii-B, iv-C
b) i-B, ii-A, iii-D, iv-C
c) i-B, ii-C, iii-A, iv-D
d) i-A, ii-B, iii-C, iv-D
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1-b
2-a
3-a
4-a
5-b
6-b
7-c
The post NIFLUMIC ACID Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
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