The post TENOXICAM Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
]]>4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-ylthieno[2,3-e]thiazine-3-carboxamide
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 337.4 g/mol |
2 | Physical appearance | Solid |
3 | Melting point | 211oC |
4 | Solubility | 14.1 mg/ml |
5 | Octanol/water partition coefficient | 1.9 |
6 | Presence of ring | Pyridine, thiophene, thiazine |
7 | Number of chiral centers | Not present |
General SAR for Oxicams can be summarized as follows:
i. Methyl 2-Methyl-4-Hydroxy-2H-Thieno[2,3-e]-1,2-Thiazine-3-Carboxylate-1,1-Dioxide is mixed with 2-aminopyridine in alkylbenzene.
ii. Alkali carbonate is added afterwards, dried and activated at 150o
iii. Crude drug is obtained from the crystals which are generated on cooling and filtering it.[2]
Tenoxicam is used for:
Side effects of Tenoxicam are:
Q.1 What can be the correct IUPAC nomenclature of Tenoxicam?
a) 4-hydroxy-2-methyl-N-(5-methyl-1,2-oxazol-3-yl)-1,1-dioxo-1λ6,2-benzothiazine-3-carboxamide
b) 4-hydroxy-2-methyl-N-(5-methyl-1,2-oxazol-3-yl)-1,1-dioxo-1λ6,2-benzothiazine-3-Carboxylic acid
c) 4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-ylthieno[2,3-e]thiazine-3-carboxamide
d) 4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-ylthieno[2,3-e]thiazine-3-Carboxylic acid
Q.2 Which amongst the following statements is/are incorrect related to the SAR of oxicams?
I. Substitution on the caboxamide with aryl group gives compounds with lesser activity than when substituents are alkyl groups.
II. N-heterocyclic compounds are less acidic than N-aryl carboxamides.
III. Primary carboxamides are more potent than secondary carboxamides.
IV. m-substituted derivatives are more potent than p-substituted derivatives.
a) I
b) II
c) I, II
d) IV
Q.3 Medicinal uses of tenoxicam is/are?
a) Treatment of pain due to rheumatoid arthritis
b) Treatment of Bradycardia
c) Reducing Blood pressure
d) All of the above
Q.4 Side effects of drug Tenoxicam is/are?
a) Ringing in ears
b) Abdominal pain
c) Easy bleeding
d) All of the above
Q.5 Match the following drugs with the correct number of the chiral carbons they have in their structure:
i. Tenoxicam | A. 5 |
ii. Bitolterol | B. 0 |
iii. Atropine | C. 4 |
iv. Metaraminol | D. 1 |
a) i-A, ii-C, iii-D, iv-B
b) i-D, ii-A, iii-C, iv-B
c) i-D, ii-B, iii-A, iv-C
d) i-B, ii-D, iii-A, iv-C
Q.6 An example of drug from class NSAIDs?
a) Tenoxicam
b) Propantheline
c) Ethopropazine
d) Salbutamol
Q.7 The type of ring system found in Tenoxicam?
I. Isoxazole
II. Pyridine
III. Thiazine
IV. Thiophene
a) I, III
b)II, III, IV
c) I, III, IV
d) II, IV
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1-c
2-c
3-a
4-d
5-d
6-a
7-b
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