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]]>N,N-dimethyl-2-[(2-methylphenyl)-phenylmethoxy]ethanamine;2-hydroxypropane-1,2,3-tricarboxylic acid.
Orphinadrine is an acetylcholine antagonist. It is a muscarinic antagonist.
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 461.5 g/mol |
2 | Physical appearance | White crystalline powder |
3 | Melting point | 132-134°C. |
4 | Solubility | Sparingly Soluble in water |
5 | Octanol/water partition coefficient | 3.77 (of orphinadrine) |
6 | Presence of ring | Benzene ring present |
7 | Number of chiral centers | 1 |
i. Reaction of N,N-dimethyl phenyl chloride and 2-methane-dimethylethanolamine produces orphenadrine.
ii. Orphenadrine is treated with citric acid to yield orphenadrine citrate.
Orphenadrine citrate is used for:
Side Effects
Side effects of Orphenadrine citrate are:
Q.1 Orphenadrine citrate?
a) Stimulate nicotinic receptors
b) Stimulates muscarinic receptors
c) Inhibits nicotinic receptors
d) Inhibits muscarinic receptors
Q.2 Therapeutic use of drug orphenadrine citrate is/are?
a) Asthma
b) Muscle spasm
c) Emphysema
d) All of the above
Q.3 Which amongst the following are the correct statements with respect to the SAR of drug Orphenadrine citrate?
I. Either R1 or R2 must be heterocyclic or carbocyclic.
II. The R3 group can be hydrogen, hydroxyl, hydroxymethyl or amide.
III. Most potent derivatives has X as an ester.
a) II
b) I
c) II, I
d) I, II, III
Q.4 The starting chemicals required for the synthesis of drug Orphenadrine citrate?
a) 2-(2’,2’-dimethoxyethyl)propane-1,3-diol.
b) 2-methyl diphenyl methyl chloride
c) N,N-dimethylethanolamine
d) Both b) and c)
Q.5 Correct sequence for the True/False for the physiochemical properties of the drug Orphenadrine citrate is?
I. Imidazole ring is present
II. Freely Soluble in water
III. Present in oil form
a) FFF
b) TTF
c) FFT
d)FTF
Q.6 Correct statements for the IUPAC nomenclatures of the are?
I. Pilocarpine: (3S,4R)-3-Ethyl-4-((1-methyl-1H-imidazol-5-yl)methyl)dihydrofuran-2(3H)-one.
II. Orphinadrine: N,N-dimethyl-2-[(2-methylphenyl)-phenylmethoxy]ethanamine;2-hydroxypropane-1,2,3-tricarboxylic acid.
III. Tiotropium: 7-[(hydroxidi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide
IV. Carbachol: 2-[(Aminocarbonyl)oxy]-N,N,N-trimethylethanaminium chloride.
a) I, III
b) II, IV
c) I, II, III, IV
d) I, II, IV
Q.7 Match the following drugs with their correct classifications-
i. Pilocarpine | A. Acetylcholinestrase inhibitor |
ii. Physostigmine | B. Acetylcholine antagonist-muscarinic antagonist |
iii. Orphenadrine | C. Acetylcholine mimetic-muscarinic agonist |
iv. Metocurine | D. Nicotinic antagonist |
a) i-C, ii-A, iii-B, iv-D
b) i-B, ii-D, iii-A, iv-C
c) i-A, ii-B, iii-D, iv-C
d) i-B, ii-C, iii-D, iv-A
1-d
2-b
3-d
4-d
5-a
6-c
7-a
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