The post PARACETAMOL (ACETAMINOPHEN) Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
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S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 151.16 g/mol |
2 | Physical appearance | White crystalline solid; forms monoclinic crystals from water |
3 | Melting point | 170°C |
4 | Solubility | Very slightly soluble in cold water; freely soluble in alcohol |
5 | Octanol/water partition coefficient | 0.46 |
6 | Presence of ring | Phenyl |
7 | Number of chiral centers | Not present |
SAR of Acetaminophen can be summarized as follows:
Acetaminophen can be synthesised by reactio of p-amiophenol with acetic anhydride. [2]
Acetaminophen is used for:
Side effects of Acetaminophen are:
Q.1 “[2-(2,6-Dichloroanilino)phenyl]acetic acid” is the IUPAC nomenclature of which drug?
a) Paracetamol
b) Acetaminophen
c) Methotrexate
d) Both a) and b)
Q.2 Types of crystals formed by paracetamol on treatment with water?
a) Monoclinic
b) Triclinic
c) Orthorhombic
d) Cubic
Q.3 Match the following with correct classifications of the drugs.
i. Acetaminophen | A. Carbamate cholinesterase inhibitor |
ii. Physostigmine | B. α-adrenergic blocker |
iii. Phentolamine | C. Benzodiazepine sedative-hypnotic |
iv. Alprazolam | D. Analgesic-antipyretic |
a) i-A, ii-D, iii-B, iv-C
b) i-D, ii-A, iii-B, iv-C
c) i-D, ii-C, iii-A, iv-B
d) i-C, ii-D, iii-A, iv-B
Q.4 Correct steps for the mechanism of action of the drug acetaminophen can be?
I. Decreases in prostaglandin synthesis
II. Increase in prostaglandin synthesis
III. Stimulation of COX-2
IV. Inhibition of COX-2
a) I – IV
b) III – II
c) IV – I
d) I – III
Q.5 Correct sequence for True and False for the given statements related with the SAR of drug acetaminophen can be?
a) TTFF
b) FFTF
c) FTFT
d) FTTF
Q.6 Acetaminophen can be synthesized by reacting acetic anhydride with?
a) p-aminophenol
b) p-aminobenzoic acid
c) 3-chlorophenol
d) tert-butyl alcohol
Q.7 The drug acetaminophen is mainly used for?
a) Reducing pain and fever
b) Systematic treatment of rheumatoid arthritis
c) Treatment of severe cholinergic toxicity
d) All of the above
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1-d
2-a
3-b
4-c
5-c
6-a
7-a
The post PARACETAMOL (ACETAMINOPHEN) Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
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