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]]>5-Ethyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
Pentobarbital is a barbiturate sedative-hypnotic.
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 226.27 g/mol |
2 | Physical appearance | Crystalline granules or white powder |
3 | Melting point | 129.5°C |
4 | Octanol/water partition coefficient | 2.1 |
5 | Solubility | Slightly soluble in water; soluble in ethyl alcohol |
6 | Presence of ring | Pyrimidine |
7 | Number of chiral centers | 1 |
i. Diethyl malonate reacts with sodium ethoxide followed by reaction with ethylbromide to give diethyl 2-ethylmalonate.
ii. The compound undergoes reaction with 2-bromopentane.
iii. The above formed compound on reaction with urea yields pentobarbital. [2]
Pentobarbital is used for:
Side effects of Pentobarbital are:
Q.1 Correct statements related with the physicochemical properties of drug Pentobarbital?
I. Molecular weight = 226.27 gm/mol
II. Physical appearance: red-brown crystalline powder
III. Melting point: 402.5K
IV. Triazole ring present
a) I, III
b) II, IV
c) I, II
d) I, II, IV
Q.2 Match the following of the drugs with their correct IUPAC names.
i. Pentobarbital | A. 5-Ethyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione |
ii. Midazolam | B. N,N-Dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide hemitartrate
|
iii. Zolpidem | C. 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine |
iv. Alprazolam | D. 8-Chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a] [1,4]benzodiazepine |
a) i-B, ii-C, iii-A, iv-D
b) i-A, ii-C, iii-B, iv-D
c) i-D, ii-A, iii-C, iv-B
d) i-B, ii-D, iii-C, iv-A
Q.3 Correct steps for the mechanism of action of the drug Pentobarbital?
I. Binds with GABAA receptors
II. Increase in GABA affinity for GABA receptors
III. Opening of chloride channel
IV. Hyperpolarisation
a) I – II – III – IV
b) II – I – III – IV
c) III – I – II – IV
d) II – IV – III – I
Q.4 Correct sequence for True/false for the classification of the drug can be?
a) TFTF
b) FFTF
c) TFFF
d) FTFT
Q.5 Triketo form of pentobarbital is?
a) Most stable in aqueous solution
b) Least stable in aqueous solution
c) Most soluble in organic solvent
d) Least soluble in organic solvent
Q.6 The correct sequence for the steps for synthesis of drug pentobarbital from diethyl malanoate is?
I. Reaction with 2-bromopentane
II. Reaction with sodium ethoxide
III. Condensation with urea.
a) III – I – II
b) I – II – III
c) I – III – II
d) II – I – III
Q.7 Side effect of drug Pentbarbital?
a) Insomnia
b) Loss of coordination
c) Nightmares
d) All of the above
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1-a
2-b
3-a
4-c
5-a
6-d
7-d
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