The post PERAMIVIR Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
]]>(1S,2S,3R,4R)-3-[(1S)-1-(Acetylamino)-2-ethylbutyl]-4-(carbamimidoylamino)-2-hydroxycyclopentanecarboxylic acid.
Peramivir is a Neuraminidase inhibitor analogue.
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 328.41 g/mol |
2 | Physical appearance | White powder |
3 | Melting point | 257-262°C |
4 | Solubility | Sparingly soluble in deionised water |
5 | Presence of ring | Cyclopentyl |
6 | Number of chiral centers | 5 |
i. Lactan is dissolved I alcoholic solution, esterification by ring opening under HCl and acid catalysis.
ii. Compound formed is reacted with hydrochloride and tert-butyl dicarbonate.
iii. Reaction with oxammonium hydrochloride reactant salt in alcohol-carbonate system.
iv. Cycloaddition reaction takes place under base catalysis.
v. Hydrogenation in alcoholic solution to generate intermediate compound.
vi. Taking off BOC protect hydrochloride
vii. Two guanidine radicals are put in the reaction vessel, system made of alcohol, organic solvent, aqueous sodium hydroxide solution.
viii. Taking off BOC, product is obtained under organic acid.
Peramivir is used for:
Side effects of Peramivir are:
MCQ
Q.1 Choose the correct statements related to the physicochemical properties of drug peramivir-
I. Molecular weight is 328.41 gm/mol
II. It is white powder in appearance
III. It is very soluble in water
IV. Melting point is 273K
a) I, II
b) I, III
c) III, IV
d) I, III, IV
Q.2 Match the following of the drugs with their correct Trade names.
i. Peramivir | A. Alkeran |
ii. Melphalan | B. Endoxan |
iii. Busulphan | C. Rapivab |
iv. Cyclophosphamide | D. Myeleran |
a) i-B, ii-C, iii-D, iv-A
b) i-B, ii-C, iii-A, iv-D
c) i-C, ii-A, iii-D, iv-B
d) i-A, ii-D, iii-B, iv-C
Q.3 Peramivir do not let the virus to?
a) Use the host machinery
b) Infect other cells
c) Grow in size
d) Synthesize DNA
Q.4 Correct sequence for True/false for the classification of the drug can be?
a) TTTT
b) TTTF
c) FTTT
d) TFTT
Q.5 Correct statement related with the SAR of Peramivir is?
a) Alkoxy derivatives have better bioavailability when administered orally
b) Alkoxy derivatives have better activity
c) Alkoxy derivatives have lower half life
d) Alkoxy derivatives have lower activity
Q.6 Type/s of ring present in the structure of peramivir?
I. Cyclopentyle
II. Imidazole
III. Benzene
a) II, III
b) I, II
c) I
d) I, II, III
Q.7 Side effect of drug peramivir?
a) Mood changes
b) Hallucinations
c) Confusion
d) All of the above
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ANSWERS
1-a
2-c
3-b
4-a
5-a
6-c
7-d
REFERENCES
[1] Laborda P, Wang SY, Voglmeir J. Influenza neuraminidase inhibitors: synthetic approaches, derivatives and biological activity. Molecules. 2016 Nov;21(11):1513.
The post PERAMIVIR Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
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