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]]>N,N-dimethyl-1-phenothiazin-10-ylpropan-2-amine
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 284.4 g/mol |
2 | Physical appearance | White to faint yellow crystalline powder |
3 | Melting point | 60oC |
4 | Solubility | Very soluble in dilute hydrogen chloride |
5 | Octanol/water partition coefficient | 4.4 |
5 | Presence of ring | Phenothiazine |
6 | Number of chiral centers | 1 |
Structure activity of phenothiazine derivatives antihistamines can be summarized as:
General structure activity of first generation H1-receptors antagonist can be summarized as:
Alkylation of phenothiazine with 1-dimethylamino-2-propylchloride gives promethazine. [1]
Promethazine is used for treatment of:
Side effects of Promethazine are:
Q.1 “N,N-dimethyl-1-phenothiazin-10-ylpropan-2-amine” is the IUPAC nomenclature of which drug?
a) Loxapine
b) Clozapine
c) Promethazine
d) Clemastine
Q.2 Melting point of Promethazine is?
a) 284oC
b) 93oC
c) 60 oC
d) 652oC
Q.3 Match the following with correct classifications of the drugs.
i. Promethazine | A. H1-receptor antihistamine |
ii. Cimetidine | B. Calcium channel blocker |
iii. Glipizide | C. Antidiabetic agent |
iv. Verapamil | D. H2-antihistamine |
a) i-A, ii-D, iii-C, iv-B
b) i-D, ii-C, iii-A, iv-B
c) i-D, ii-A, iii-B, iv-C
d) i-B, ii-D, iii-A, iv-C
Q.4 Mechanism of action of Promethazine includes?
I. Antagonistic effects on H1-receptor.
II. Antagonistic effects on H2-receptor.
III. Effects on Muscarinic receptors
IV. Reduction in acidity of stomach
a) I, II
b) II, IV
c) I, II, III
d)I, III
Q.5 Correct sequence for True and False for the given statements related with the SAR of Phenothiazine derivatives antihistamines drugs can be?
a) TTFT
b) TFTF
c) TTTT
d) FFTT
Q.6 Reaction of phenothiazine with 1-dimethylamino-2-propylchloride produces which drug?
a) Promazine
b) Clonidine
c) Mechlorethamine
d) None of the above
Q.7 The drug Promethazine is mainly used for treatment of?
a) Nausea
b) Motion sickness
c) Tension
d) All of the above
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1-c
2-c
3-a
4-d
5-c
6-d
7-d
The post PROMETHAZINE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
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