The post PHENACEMIDE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
]]>N-Carbamoyl-2-phenyl-acetamide
Phenacemide is an acetylurea derivative anticonvulsant.
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 178.19 g/mol |
2 | Physical appearance | White to creamy white crystalline solid. |
3 | Melting point | 215°C |
4 | Solubility | Very slightly soluble in water; slightly soluble I benzene, chloroform, alcohol, ether. |
5 | Octanol/water partition coefficient | 0.87 |
6 | Presence of ring | Phenyl |
7 | Number of chiral centers | Not present |
i. Phenacemide binds and blocks neuronal sodium channels / voltage sensitive calcium channels.
ii. This results in blockage or suppression of neuronal depolarization and hypersynchronization.
iii. Seizures cause due to hypersynchronization is controlled.
SAR of phenylacylureas can be summarized as follows:
Phenacemide can be synthesized by reacting 2-phenylacetyl chloride with urea.
Phenacemide is used for:
Side effects of Phenacemide are:
Q.1 Choose the correct statements related with the physicochemical properties of drug phenacemide.
I. Molecular weight = 178.19 gm/mol
II. It is a creamy white crystalline solid
III. Melting point is 215oC
IV. It is freely soluble in water
a) I, III, IV
b) II, IV
c) I, IV
d) I, II, IV
Q.2 Match the following of the drugs with their correct IUPAC names.
i. Phenacemide | A. 4-[bis(2-Chloroethyl)amino]-L-phenylalanine |
ii. Melphalan | B. 1,1′,1′′-Phosphorothioyltriaziridine |
iii. Chlorambucil | C. 4-[bis(2-chlorethyl)amino]benzenebutanoic acid |
iv. Thiotepa | D. N-Carbamoyl-2-phenyl-acetamide |
a) i-C, ii-A, iii-B, iv-D
b) i-D, ii-A, iii-C, iv-B
c) i-D, ii-A, iii-B, iv-C
d) i-A, ii-C, iii-B, iv-D
Q.3 Correct steps for the mechanism of action of the drug Phenacemide are?
I. Suppression of neuronal depolarizatioon
II. Stimulation of neuronal depolarization
III. Blocking of neuronal sodium channel
IV. Agonistic effect on neuronal sodium channels
a) I – III
b)II – III
c) III – I
d) IV- II
Q.4 Correct sequence for True/false for the classification of the drug can be?
a) TFFT
b) TTTT
c) TFFT
d) FFTF
Q.5 Increase in weight of phenylacylureas leads to?
a) Increase in anticonvulsant properties
b) Decreases in anticonvulsant properties
c) No changes in anticonvulsant activity
d) Unpredictable changes
Q.6 The two chemicals which on reaction with each other produces Phenacemide?
I. 2-phenylacetyl chloride
II. 3-hydroxy-butanoyl chloride
III. Urea
IV. Aniline
a) II, IV
b) II, IV
c) I, III
d) I, II
Q.7 Side effect of drug phenacemide include?
a) Abdominal pain
b) Liver problems
c) Low blood counts
d) All of the above
Participate in Online FREE GPAT TEST: CLICK HERE
Participate in Online FREE Pharmacist TEST: CLICK HERE
Participate in Online FREE Drug Inspector TEST: CLICK HERE
1-d
2-b
3-c
4-b
5-b
6-c
7-d
The post PHENACEMIDE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
]]>