The post PHENINDAMINE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
]]>IUPAC nomenclature
2-methyl-9-phenyl-2,3,4,9-tetrahydro-1H-indeno[2,1-c]pyridine
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 261.4 g/mol |
2 | Physical appearance | Solid |
3 | Melting point | 91oC |
4 | Solubility | 2.77e-02 g/L |
5 | Octanol/water partition coefficient | N/A |
5 | Presence of ring | Indenopyridine, phenyl |
6 | Number of chiral centers | 1 |
Structure activity of alkyl amines antihistamines can be summarized as:
Phenindamine is used for treatment of:
Side effects of Phenindamine are:
Q.1 Match the following with correct SAR of the alkylamines antihistamine drugs:
i. E-isomers are | A. More potent than Z-isomers |
ii. S-enantiomers have | B. Less potent than Z-isomers |
C. Greater affinity for H1-receptors | |
D. Greater affinity for H2-receptors |
Q.2 Correct sequence for the True/False for correct IUPAC names of the drug can be?
a) TFFT
b) FFTF
c) TTTT
d) FFFT
Q.3 Molecular weight of Phenindamine is?
a) 200.5 gm/mol
b) 540.6 gm/mol
c) 261.4 gm/mol
d) 1042 gm/mol
Q.4 Phenindamine binds with which receptor to produce antihistaminic actions?
a) α-receptors
b) ß-receptors
c) Nicotinic receptor
d) H1-receptor
Q.5 Which amongst the following is not a therapeutic use of drug phenindamine?
a) Runny nose
b) Sneezing
c) Hay fever
d) Hypertension
Q.6 Which of the following drug and their classification are correct?
I. Phenindamine: H1 receptor antihistamine drug
II. Cimetidine: H2 receptor antihistamine drug
III. Lansoprazole: Proton pump inhibitor
IV. Thiotepa: Antineoplastic drug
a) I, III
b) I, II, III, IV
c) III, IV
d) I, II, IV
Q.7 Number of chiral centers present in the structure of phenindamine is?
a) 0
b) 1
c) 2
d) 3
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ANSWERS
1-a
2-c
3-c
4-d
5-d
6-b
7-b
REFERENCES
[1] Lemke TL, Williams DA, editors. Foye’s principles of medicinal chemistry. Lippincott Williams & Wilkins; 2012 Jan 24. [2] US 2 470 108 (Roche; 1949; appl. 1947).The post PHENINDAMINE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
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