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]]>1-methyl-3-phenyl-pyrrolidine-2,5-dione
Phensuximide is a succinimide anticonvulsant.
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 189.21 g/mol |
2 | Physical appearance | Present in solid form |
3 | Melting point | 72°C |
4 | Solubility | 7020 mg/L |
5 | Octanol/water partition coefficient | 0.7 |
6 | Presence of ring | Pyrrolidine, phenyl |
7 | Number of chiral centers | 1 |
SAR of succinimides can be discussed as follows:
Phensuximide can be synthesized by the reaction of phenylsuccinic acid or its anhydride with methylamine. [1]
Phensuximide is used for:
Side effects of Phensuximide are:
Q.1 “1-methyl-3-phenyl-pyrrolidine-2,5-dione” is the IUPAC nomenclature of which drug?
a) Phensuximide
b) Halothane
c) Dutasteride
d) Fulvestrant
Q.2 Correct melting point of the drug Phensuximide is?
a) 72°C
b) 172°C
c) 272°C
d) 372°C
Q.3 Match the following with correct classifications of the drugs.
i. Phensuximide | A. Inhalational anesthetics |
ii. Oxazepam | B. ß-blockers |
iii. Halothane | C. Sedative hypnotic |
iv. Esmolol | D. Anticonvulsant drug |
a) i-A, ii-C, iii-D, iv-B
b) i-C, ii-A, iii-B, iv-D
c) i-D, ii-C, iii-A, iv-B
d) i-A, ii-D, iii-C, iv-B
Q.4 Mechanism of action of drug phensuximide includes?
I. Inhibition of neuronal systems that is important for generation of three per second rhythm.
II. Inhibition of depolarization-induced accumulation of cyclic adenosine monophosphate and GMP in brain tissues.
III. Inhibits releases of Acetylcholine from the presynaptic nerves.
IV. Antagonizes the muscarinic receptors.
a) I, IV
b) II, III
c) I, III, IV
d) I, II
Q.5 Correct sequence for True and False for the given statements related with the SAR of succinimide drugs?
a) FFT
b) TFT
c) TFF
d) FFF
Q.6 Which drug is formed on reaction of phenylsuccinic acid with methylamine?
a) Halothane
b) Oxazepam
c) Phensuximide
d) Piperacetazine
Q.7 The drug Phensuximide is mainly used for?
a) Treatment of epilepsy
b) Treatment of pain due to gout
c) As an antiviral drug
d) All of the above
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1-a
2-a
3-c
4-d
5-b
6-c
7-a
REFERENCES
[1] Vardanyan R, Hruby V. Synthesis of essential drugs. Elsevier; 2006 Mar 10.The post PHENSUXIMIDE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
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