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6-chloro-2-methyl-3-{[(2,2,2-trifluoroethyl)thio]methyl}-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 439.9 g/mol |
2 | Physical appearance | White crystalline powder |
3 | Melting point | 214oC |
4 | Solubility | Soluble in methanol, acetone and dimethylformamide; practically insoluble in water |
5 | Octanol/water partition coefficient | 1.9 |
5 | Presence of ring | Benzothiazine |
6 | Number of chiral centers | Not present |
General structure activity of thiazide diuretics can be summarized as:
.Condensation of 4-aminosulfonyl-5-chloro-2-methyl-aminosulfonylaniline with the help of 2,2,2-trifluoroethylthioacetaldehyde dimethylacetal produces polythiazide drug.
Polythiazide is used for:
Side effects of polythiazide are:
Q.1 “6-chloro-2-methyl-3-{[(2,2,2-trifluoroethyl)thio]methyl}-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide” is the IUPAC nomenclature of which drug?
a) Polythiazide
b) Atropine
c) Amlodipine
d) Tropicamide
Q.2 Melting point of drug Polythiazide is?
a) 408.9oC
b) 214 oC
c) 345 oC
d) 741 oC
Q.3 Match the following with correct classifications of the drugs.
i. Polythiazide | A. Narcotic antagonist |
ii. Phensuximide | B. Anticonvulsant |
iii. Pentobarbital | C. Sedative-hypnotics |
iv. Nalorphine | D. Calcium channel blocker |
a) i-C, ii-A, iii-D, iv-B
b) i-D, ii-C, iii-A, iv-B
c) i-D, ii-B, iii-C, iv-A
d) i-C, ii-D, iii-B, iv-A
Q.4 Mechanism of action of the drug Polythiazide includes?
I. Prevention of active chloride reabsorption.
II. Binding with thiazide-sensitive Na-Cl transportor
III. Increase in excretion of water from the body.
a) I, II, III
b) II, III
c) I, III
d) I, II
Q.5 Correct sequence for True and False for the given statements related with the SAR of Thiazide diuretics can be?
a) TFF
b) FFT
c) TTF
d) FFF
Q.6 Number of chiral carbons present in the structure of polythiazide is?
a) 0
b) 1
c) 2
d) 3
Q.7 The drug Polythiazide is mainly used for?
a) Reducing edema
b) Treatment of hypotension
c) Treatment of asthma
d) All of the above
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1-a
2-b
3-c
4-a
5-c
6-a
7-a
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