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]]>5-Ethyl-5-phenyl-1,3-diazinane-4,6-dione
Primidone belongs to barbiturate anticonvulsive drug class.
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 218.25 g/mol |
2 | Physical appearance | White crystalline powder |
3 | Melting point | 281.5°C |
4 | Solubility | 480 mg/L in water |
5 | Octanol/water partition coefficient | 0.91 |
6 | Presence of ring | Pyrimidine, phenyl |
7 | Number of chiral centers | Not present |
i. Diethyl phenylethylmalanoate and thiourea undergoes condensation reaction to form Phenobarbital sodium.
ii. Phenobarbital sodium acidizes to synthesize thio Phenobarbital
iii. By using lower alcohols as solvent and palladium on carbon as a catalyst, Phenobarbital undergoes high pressure hydrogenation reduction to yield primidone
Primidone is used for:
Side effects of Primidone are:
Q.1 What can be the correct IUPAC nomenclature of Primidone?
a) 5-Ethyl-5-phenyl-1-azinane-4,6-dione
b) 5-Ethyl-5-phenyl-1,3-diazinane-4,6-dione
c) (RS)-1,3-dimethyl-3-phenyl-pyrrolidine-2,5-dione
d) (RS)-1,3-dimethyl-3-phenyl-pyrrolidine-2-one
Q.2 Which amongst the following statements is/are incorrect related to the SAR of Primidone?
I. Tri-keto form is least stable in aqueous solution.
II. 4,6-dialcoholic tautomeric forms are least stable in aqueous solution.
III. 5,5-disubstituted barbituric acid is the prime requirement for the barbituares to be sedative hypnotics.
a) I, II
b) I
c) III
d) II, III
Q.3 Primidone can be synthesized by hydrogenation reduction of?
a) Thiophenobarbital sodium
b) Phenobarbital
c) Thiophenobarbital
d) Barbituric acid
Q.4 Side effects of drug Primidone is/are?
a) Shallow breathing
b) Decreased libido
c) Clumsiness
d) All of the above
Q.5 Match the following drugs with their correct molecular weight.
i. Primidone | A.443.6 gm/mol |
ii. Risperidone | B. 379.4 gm/mol |
iii. Tiotixene | C. 410.5 gm/mol |
iv. Droperidol | D.218.25 gm/mol |
a) i-A, ii-D, iii-C, iv-B
b) i-B, ii-A, iii-D, iv-C
c) i-A, ii-C, iii-D, iv-B
d) i-D, ii-C, iii-A, iv-B
Q.6 An example of drug from class Barbiturate anticonvulsant is?
a) Primidone
b) Esmolol
c) Methotrexate
d) Carboplatin
Q.7 The type of ring system found in the structure of Primidone is?
a) Pyridine
b) Pyrimidine
c) Cyclohexane
d) Furan
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1-b
2-b
3-c
4-d
5-d
6-a
7-b
The post PRIMIDONE Synthesis, SAR, MCQ, Structure, Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
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