The post PROMAZINE HYDROCHLORIDE Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
]]>N,N-dimethyl-3-phenothiazin-10-ylpropan-1-amine;hydrochloride.
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 320.9 g/mol |
2 | Physical appearance | Solid |
3 | Melting point | 174-176°C |
4 | Solubility | >48.1 ug/ml |
5 | Octanol/water partition coefficient | logP = 2.94 |
6 | Presence of ring | Phenothiazine |
7 | Number of chiral centers | Not present |
The post synaptic dopamine receptors D1 and D2 in the mesolimbic and medullary chemoreceptor trigger zone is blocked by Promazine hydrochloride. This results in decrease in stimulation of the vomiting center in the brain and psychotic effects including hallucinations and delusions.
Promazine hydrochloride also blocks α-adrenergic receptors and thus exhibit strong anticholinergic activity.
Structure activity relationship of phenothiazine can be described as follows:
i. Diphenylamine reacts with sulfur to give phenothiazine.
ii. Promazine can be synthesized from phenothiazine by alkylation with 3-dimethylaminopropylchloride in the presence of sodium amide. [2]
Promazine hydrochloride is used for:
Side effects of Promazine hydrochloride are:
Q.1 “N,N-dimethyl-3-phenothiazin-10-ylpropan-1-amine” is the IUPAC nomenclature of which drug?
a) Promazine
b) Chlorpromazine
c) Chlordiazepoxide
d) Phenobarbiton
Q.2 The approximate molecular weight of the drug promazine hydrochloride is?
a) 320 gm/mol
b) 222 gm/mol
c) 545 gm/mol
d) 465 gm/mol
Q.3 Match the following with correct classifications of the drugs.
i. Promazine | A. 5-HT receptor antagonist |
ii. Lysergic acid diethylamide | B. Hallucinogenic agent |
iii. Alosetron | C. 5-HT receptor agonist |
iv. Eletriptan | D. Phenothiazine |
a) i-B, ii-A, iii-C, iv-D
b) i-D, ii-A, iii-B, iv-C
c) i-A, ii-B, iii-D, iv-C
d) i-D, ii-B, iii-A, iv-C
Q.4 Type of receptors with which promazine interacts?
I. Dopamine D1 receptors
II. Dopamine D2 receptos
III. α-adrenoceptors
IV. ß-adrenoceptor
a) I, II
b) III, IV
c) I, II, III
d) II, III, IV
Q.5 Correct sequence for True and False for the given statements related with the SAR of drug promazine hydrochloride?
a) TFTT
b) TTFF
c) FFTT
d) FFTF
Q.6 Promazine can be synthesized from phenothiazine through alkylation by?
a) 3-dimethylaminobutylchloride
b) 2-dimethylaminopropylchloride
c) 3-dimethylaminopropylchloride
d) 2-dimethylaminobutylchloride
Q.7 The drug promazine hydrochloride is mainly used for?
a) Treatment of Panic attacks
b) Treatment of Schizophrenia
c) Prevention of Arrythmias
d) All of the above
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1-a
2-a
3-d
4-c
5-b
6-c
7-b
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