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]]>Methyl-di(propan-2-yl)-[2-(9H-xanthene-9-carbonyloxy)ethyl]azanium
Propantheline is an acetylcholine antagonist. It is a muscarinic antagonist.
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 368.5 g/mol |
2 | Physical appearance | Solid |
3 | Melting point | 152-162°C |
4 | Solubility | Very soluble in water |
5 | Presence of ring | Xanthenes |
6 | Number of chiral centers | Not present |
Propantheline reduces the effect of acetylcholine by blocking the receptors for acetylcholine on smooth muscles. It’s effects also includes the direct relaxation of the smooth muscles. [1]
i. Xanthene-9-carboxylic acid chloride reacts with 2-diisopropylaminoethanol.
ii. Alkylation of the formed compound using methyl bromide gives propantheline.
Propantheline is used for:
Side effects of propantheline are:
Q.1 “Methyl-di(propan-2-yl)-[2-(9H-xanthene-9-carbonyloxy)ethyl]azanium” is the IUPAC nomenclature of which drug?
a) Trihexyphenidyl
b) Propantheline
c) Oxybutynin
d) Oxazepam
Q.2 Melting point of Propantheline is?
a) 152-162°C
b) 129-130°C
c) 205.5°C
d) 258.5°C
Q.3 Match the following with correct classifications of the drugs.
i. Propantheline | A. Benzodiazepine sedative-hypnotic |
ii. Oxazepam | B. Barbiturate |
iii. Clozapine | C. Muscarinic antagonist |
iv. Thiamylal | D. Benzpines |
a) i-A, ii-C, iii-D, iv-B
b) i-C, ii-A, iii-D, iv-B
c) i-A, ii-B, iii-D, iv-C
d) i-C, ii-B, iii-A, iv-D
Q.4 Mechanism of action of Propantheline is based on?
a) Blocking the Muscarinic acetylcholine receptors
b) Blocking the nicotinic acetylcholine receptors
c) Direct relaxation of smooth muscles
d) Both a) and c)
Q.5 Correct sequence for True and False for the given statements related with the SAR of drug trihexyphenidyl
a) TFTF
b) FTFT
c) TTTT
d)FFTF
Q.6 Steps involved in the synthesis of Propantheline from xanthenes-9-carboxylic acid chloride in the correct sequence is?
I. Reaction with 2-diisopropylaminoethanol
II. Grignard’s reaction with cyclohexylmagnesium chloride
III. Alkylation using methylbromide
a) I – II – III
b) I – III
c) I – II
d) II – I – III
Q.7 The drug Propantheline is mainly used for?
a) Parkinson’s disease
b) Muscle spasm
c) Depression
d) Constipation
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1-b
2-a
3-b
4-d
5-c
6-b
7-b
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