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]]>1-[(2E)-4-(4-chlorophenyl)-3-phenylbut-2-en-1-yl]pyrrolidine
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 311.8 g/mol |
2 | Physical appearance | N/A |
3 | Melting point | N/A |
4 | Solubility | N/A |
5 | Presence of ring | Pyrrolidine, phenyl |
6 | Number of chiral centers | Not present |
Pyrrobutamine do competition for H1 receptor with histamine and after bounding with receptor, it acts as inverse agonist.
Structure activity of alkyl amines antihistamines can be summarized as:
i. Acetophenone, paraformaldehyde and pyrrolidine are reacted together to form 3-pyrrolidinopropiophenone.
ii. Last reacts with 4-chlorobenzyl magnesium chloride to give 1-(4-chlorophenyl)-2-phenyl-4-(pyrrolidin-1-yl)butan-2-ol.
iii. Above formed compound is treated with hydrochloric acid to produce pyrrobutamine. [2]
Pyrrobutamine is used for treatment of:
Side effects of pyrrobutamine are:
Q.1 Match the following with correct SAR of the Alkylamine antihistamine drugs-
i. E-isomers in alkenes are | A. More potent than Z-isomers |
ii. S-enantiomers have | B. Less potent than Z-isomers |
C. Greater affinity for H1 histamine receptors | |
D. Lesser affinity for H1 histamine receptors |
a) i-A, ii-C
b) i-A, ii-D
c) i-B, ii-D
d) i-B, ii-C
Q.2 Correct sequence for the True/False for correct IUPAC names of the drug can be?
a) TFFF
b) FFTT
c) FTFT
d) TTTT
Q.3 Number of chiral carbons present in the structure of pyrrobutamine is?
a) 0
b) 1
c) 2
d) 3
Q.4 Pyrrobutamine acts as reverse agonist for?
a) H1 receptors
b) H2 receptors
c) Muscarinic receptors
d) Nicotinic receptors
Q.5 Which amongst the following is not a therapeutic use of drug Pyrrobutamine?
a) Treatment of arrhythmias
b) Treatment of Allergic symptoms
c) Treatment of hay fever
d) Treatment of Runny nose
Q.6 Which of the following drug and their classification are correct?
I. Pyrrobutamine: Ethanolamine ether antihistamine drug
II. Enflurane: Inhalational anesthetics
III. Diazepam: Alpha adrenergic blockers
IV. Sulpieride: Benzodiazepine sedative hypnotics
a) I, IV
b) I, II
c) II, III
d) III, IV
Q.7 Type of ring structure present in the structure of pyrrobutamine?
a) Pyridine
b) Purine
c) Pyrrolidine
d) Pyran
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1-a
2-a
3-a
4-a
5-a
6-b
7-c
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