The post IVERMECTIN Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
]]>22,23-dihydroavermectin B1a + 22,23-dihydroavermectin B1b.
Ivermectin is an avermectin analogue. It is a broad spectrum anti-parasite medication. Antihelmintics.
S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
1 | Molecular weight | 875.1g/mol |
2 | Physical appearance | White to yellowish white crystalline powder |
3 | Melting point | 155°C |
4 | Solubility | 0.005mg/ml in water |
6 | Presence of ring | Furane, pyrane |
7 | Number of chiral centers | 20 |
Structure Activity Relationship
Selective, catalytic hydrogenation of the cis-22,23-double bond of the avermectins N1a and B1b. Catalyst used is Wilkinson’s catalyst chlorotris(triphenylphosphine)rhodium(I) {RhCl(PPh3)3].
Ivermectin is used for the treatment of certain parasitic roundworm infections.
Currently investigated for COVID-19 Treatment in Australia
Side effects of Ivermectin are:
MCQ
Q.1 What can be the correct IUPAC nomenclature of the drug ivermectn?
a) 22,23-dihydroavermectin B1a
b) 22,23-dihydroavermectin B1b
c) Both a) and b)
d) None of the above
Q.2 Which amongst the following statements is/are incorrect related to the SAR of ivermectin?
I. 4’-O-substituted derivatives retains biological activity.
II. 5-O-substituted analogue has maximum biological activity.
III. Presence of hydroxy or methoxy group at 5-position is essential for antiparasitic activity.
IV. The presence of two sugar moieties at position 13 is essential for biological activity.
a) I
b) II
c) III
d) IV
Q.3 Ivermectin can be synthesized from avermectin by ?
a) Hydrogenation
b) Oxidation
c) Chlorination
d) Alkylation
Q.4 Side effects of drug Ivermectin is/are?
a) Headache
b) Swelling of lymph nodes
c) Diarrhea
d) All of the above
Q.5 Match the following drugs with their correct molecular weights-
i. Ivermectin | A. 875.1 gm/mol |
ii. Chloraquine | B. 319.9 gm/mol |
iii. Nitrazepam | C.281.27 gm/mol |
iv. Zaleplon | D. 305.33 gm/mol |
a) i-C, ii-B, iii-D, iv-A
b) i-A, ii-B, iii-C, iv-D
c) i-B, ii-D, iii-C, iv-A
d) i-D, ii-A, iii-C, iv-B
Q.6 An example of drug from class antihelminthics ?
a) Ivermectin
b) Diazepam
c) Fludarabine
d) Pentobarbital
Q.7 Number of chiral centers present in the structure of Ivermectin is?
a) 5
b) 10
c) 15
d) 20
Participate in Online FREE GPAT TEST: CLICK HERE
Participate in Online FREE Pharmacist TEST: CLICK HERE
Participate in Online FREE Drug Inspector TEST: CLICK HERE
1-c
2-b
3-a
4-d
5-b
6-a
7-d
The post IVERMECTIN Synthesis, SAR, MCQ,Structure,Chemical Properties and Therapeutic Uses appeared first on Gpatindia: Pharmacy Jobs, Admissions, Scholarships, Conference,Grants, Exam Alerts.
]]>